| Texto completo | |
| Autor(es): |
Shimoura, Caroline G.
;
Oliveira, Tales L.
;
Lincevicius, Gisele S.
;
Crajoinas, Renato O.
;
Oliveira-Sales, Elizabeth B.
;
Varela, Vanessa A.
;
Gomes, Guiomar N.
;
Bergamaschi, Cassia T.
;
Campos, Ruy R.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 25, n. 13, p. 13-pg., 2024-07-01. |
| Resumo | |
The Goldblatt model of hypertension (2K-1C) in rats is characterized by renal sympathetic nerve activity (rSNA). We investigated the effects of unilateral renal denervation of the clipped kidney (DNX) on sodium transporters of the unclipped kidneys and the cardiovascular, autonomic, and renal functions in 2K-1C and control (CTR) rats. The mean arterial pressure (MAP) and rSNA were evaluated in experimental groups. Kidney function and NHE3, NCC, ENaC beta, and ENaC gamma protein expressions were assessed. The glomerular filtration rate (GRF) and renal plasma flow were not changed by DNX, but the urinary (CTR: 0.0042 +/- 0.001; 2K-1C: 0.014 +/- 0.003; DNX: 0.005 +/- 0.0013 mL/min/g renal tissue) and filtration fractions (CTR: 0.29 +/- 0.02; 2K-1C: 0.51 +/- 0.06; DNX: 0.28 +/- 0.04 mL/min/g renal tissue) were normalized. The Na+/H+ exchanger (NHE3) was reduced in 2K-1C, and DNX normalized NHE3 (CTR: 100 +/- 6; 2K-1C: 44 +/- 14, DNX: 84 +/- 13%). Conversely, the Na+/Cl- cotransporter (NCC) was increased in 2K-1C and was reduced by DNX (CTR: 94 +/- 6; 2K-1C: 144 +/- 8; DNX: 60 +/- 15%). In conclusion, DNX in Goldblatt rats reduced blood pressure and proteinuria independently of GRF with a distinct regulation of NHE3 and NCC in unclipped kidneys. (AU) | |
| Processo FAPESP: | 19/25295-0 - Comunicação entre o sistema nervoso central e rins: influências cardiovasculares, renais e autonômicas em condições fisiológicas e fisiopatológicas |
| Beneficiário: | Ruy Ribeiro de Campos Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |