Autor(es)

Fernandes-Junior, Wilson S. ; Orzari, Luiz O. ; Kalinke, Cristiane ; Bonacin, Juliano A. ; Janegitz, Bruno C.

• Tipo de documento: Artigo Científico
• Fonte: Talanta; v. 275, p. 10-pg., 2024-05-03.

Resumo

Additive manufacturing is a technique that allows the construction of prototypes and has evolved a lot in the last 20 years, innovating industrial fabrication processes in several areas. In chemistry, additive manufacturing has been used in several functionalities, such as microfluidic analytical devices, energy storage devices, and electrochemical sensors. Theophylline and paracetamol are important pharmaceutical drugs where overdosing can cause adverse effects, such as tachycardia, seizures, and even renal failure. Therefore, this paper aims at the development of miniaturized electrochemical sensors using 3D printing and polylactic acid-based conductive carbon black commercial filament for theophylline and paracetamol detection. Electrochemical characterizations of the proposed sensor were performed to prove the functionality of the device. Morphological characterizations were carried out, in which chemical treatment could change the surface structure, causing the improvement of the analytical signal. Thus, the detection of theophylline at a linear range of 5.00 - 150 mu mol L -1 with a limit of detection of 1.2 mu mol L -1 was attained, and the detection of paracetamol at a linear range of 1.00 - 200 mu mol L -1 with a limit of detection of 0.370 mu mol L -1 was obtained, demonstrating the proposed sensor effectively detected pharmaceutical drugs. (AU)

• Processo FAPESP: 19/23342-0 - Desenvolvimento de novas arquiteturas de imunossensores para a detecção de biomarcadores das Doenças de Huntington e Parkinson
• Beneficiário: Luiz Otávio Orzari
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/26953-0 - Sensores e biossensores eletroquímicos impressos em 3D utilizando filamento de grafeno para a detecção de compostos fenólicos
• Beneficiário: Wilson da Silva Fernandes Junior
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/21097-3 - Interações abelha-agricultura: perspectivas para a utilização sustentável
• Beneficiário: Osmar Malaspina
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 19/00473-2 - Desenvolvimento de biossensores eletroquímicos impressos em 3 dimensões (3D) com polímero PLA e grafeno para a determinação de biomoléculas e diagnóstico de doenças
• Beneficiário: Cristiane Kalinke
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado