| Texto completo | |
| Autor(es): |
Godoi, Juannicelle
;
Negrini, Silvia
;
Aragon, Davi
;
Rocha, Paulo
;
Amaral, Fabiana
;
Negrini, Bento
;
Teixeira, Sara
;
Yamamoto, Aparecida
;
Bettiol, Heloisa
;
Mussi-Pinhata, Marisa
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PATHOGENS; v. 12, n. 10, p. 11-pg., 2023-10-01. |
| Resumo | |
Although very few controlled studies are available, in utero Zika virus (ZIKV)-exposed children are considered at risk for neurodevelopmental abnormalities. We aimed to identify whether there is an excess risk of abnormalities in non-microcephalic children born to mothers with confirmed ZIKV infection compared with ZIKV-unexposed children from the same population. In a cross-sectional study nested in two larger cohorts, we compared 324 ZIKV-exposed children with 984 unexposed controls. Outcomes were assessed using the Bayley Screening Test III applied around 24 months of age. Relative risks for classifying children as emergent or at-risk for neurodevelopmental delay in at least one of five domains were calculated, adjusting for covariates. In four of the five domains, few children were classified as emergent (4-12%) or at-risk (0.3-2.16%) but for the expressive communication domain it was higher for emergent (19.1-42.9%). ZIKV-exposed children were half as frequently classified as emergent, including after adjusting for covariates [RR = 0.52 (CI 95% 0.40; 0.66)]. However, no difference was detected in the at-risk category [RR = 0.83 (CI 95% 0.48; 1.44)]. Normocephalic children exposed to the Zika virus during pregnancy do not have a higher risk of being classified as at risk for neurodevelopmental abnormalities at two years of age. (AU) | |
| Processo FAPESP: | 08/53593-0 - Fatores etiológicos da prematuridade e conseqüências dos fatores perinatais na saúde da criança: coortes de nascimentos em duas cidades brasileiras |
| Beneficiário: | Marco Antonio Barbieri |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |