Influence of GB virus C on IFN-gamma and IL-2 production and CD38 expression in T lymphocytes from chronically HIV-infected and HIV-HCV-co-infected patients

Autor(es)

Baggio-Zappia, Giovana Lotici ^[1] ; Barbosa, Aline de Jesus ^[1] ; Colo Brunialti, Milena Karina ^[1] ; Salomao, Reinaldo ^[1] ; Hernandes Granato, Celso Francisco ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Disciplina Infectol, Lab Virol & Imunol, BR-04039032 Sao Paulo - Brazil

^[2] Fleury Med Diagnost, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 106, n. 6, p. 662-669, SEP 2011.
• Citações Web of Science: 5

Resumo

This study was designed to assess the effect of GB virus (GBV)-C on the immune response to human immunodeficiency virus (HIV) in chronically HIV-infected and HIV-hepatitis C virus (HCV)-co-infected patients undergoing antiretroviral therapy. A cohort of 159 HIV-seropositive patients, of whom 52 were HCV-co-infected, was included. Epidemiological data were collected and virological and immunological markers, including the production of interferon gamma (IFN-gamma) and interleukin (IL)-2 by CD4, CD8 and T gamma delta cells and the expression of the activation marker, CD38, were assessed. A total of 65 patients (40.8%) presented markers of GBV-C infection. The presence of GBV-C did not influence HIV and HCV replication or TCD4 and TCD8 cell counts. Immune responses, defined by IFN-gamma and IL-2 production and CD38 expression did not differ among the groups. Our results suggest that neither GBV-C viremia nor the presence of E2 antibodies influence HIV and HCV viral replication or CD4 T cell counts in chronically infected patients. Furthermore, GBV-C did not influence cytokine production or CD38-driven immune activation among these patients. Although our results do not exclude a protective effect of GBV-C in early HIV disease, they demonstrate that this effect may not be present in chronically infected patients, who represent the majority of patients in outpatient clinics. (AU)

• Processo FAPESP: 05/58901-7 - Avaliação de parâmetros da resposta imunológica na co-infecção pelo HIV-1 e vírus das hepatites C e G (HGV/GBV-C)
• Beneficiário: Giovana Lótici Baggio
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 05/57611-5 - Importancia clinica e impactos imunologico e virologico da co-infeccao hiv/hcv/gbv-c-hgv.
• Beneficiário: Celso Francisco Hernandes Granato
• Modalidade de apoio: Auxílio à Pesquisa - Regular