Haematological and immunological effects of repeated dose exposure of rats to integerrimine N-oxide from Senecio brasiliensis

Autor(es)

Elias, Fabiana ^{[1, 2]} ; Latorre, Andreia O. ^[1] ; Pipole, Fernando ^[1] ; Haraguchi, Mitsue ^[3] ; Gorniak, Silvana L. ^[1] ; Hueza, Isis M. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Res Ctr Vet Toxicol CEPTOX, Dept Pathol, Sch Vet Med & Anim Sci, BR-05508270 Pirassununga, SP - Brazil

^[2] UPIS Fac Integradas, Sch Vet, BR-70390125 Brasilia, DF - Brazil

^[3] Inst Biol, BR-04014002 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food and Chemical Toxicology; v. 49, n. 9, p. 2313-2319, SEP 2011.
• Citações Web of Science: 4

Resumo

This study is the first in the literature to focus attention on the possible immunotoxic effect of integerrimine N-oxide content in the butanolic residue (BR) of Senecio brasiliensis, a poisonous hepatotoxic plant that contains pyrrolizidine alkaloids (PAs). PAs have been reported as a pasture and food contaminant and as herbal medicine used worldwide and are responsible for poisoning events in livestock and human beings. After the plant extraction, BR extracted from Senecio brasiliensis was found to contain approximately 70% integerrimine N-oxide by elemental and spectral analyses ((1)H and (13)C NMR), which was administered to adult male Wistar Hannover rats at doses of 3, 6 and 9 mg/kg for 28 days. Body weight gain, food consumption, lymphoid organs, neutrophil analysis, humoural immune response, cellular immune response and lymphocyte analysis were evaluated. Our study showed that integerrimine N-oxide could promote an impairment in the body weight gain, interference with blood cell counts and a reducing T cell proliferative activity in rats; however, no differences in the neutrophil activities, lymphocytes phenotyping and humoural and cellular immune responses were observed. It is concluded that doses of integerrimine N-oxide here employed did not produce marked immunotoxic effects. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 07/51648-0 - Avaliacao dos possiveis efeitos toxicos da monocrotalina sobre a resposta imune inata de ratos adultos e da prole de ratas tratadas durante a gestacao.
• Beneficiário: Julia Cristina Benassi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica