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Cardiorespiratory abnormalities in ICU survivors of COVID-19 with postacute sequelae of SARS-CoV-2 infection are unrelated to invasive mechanical ventilation

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Longobardi, Igor ; do Prado, Danilo Marcelo Leite ; de Andrade, Danieli Castro Oliveira ; Goessler, Karla Fabiana ; de Oliveira Junior, Gersiel Nascimento ; Azevedo, Rafael de Almeida ; Leitao, Alice Erwig ; Santos, Jhonnatan Vasconcelos Pereira ; Pinto, Ana Lucia de Sa ; Gualano, Bruno ; Roschel, Hamilton
Número total de Autores: 11
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 326, n. 4, p. 9-pg., 2024-04-09.
Resumo

Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) often leads to exertional intolerance and reduced exercise capacity, particularly in individuals previously admitted to an intensive care unit (ICU). However, the impact of invasive mechanical ventilation (IMV) on PASC-associated cardiorespiratory abnormalities during exercise remains poorly understood. This single-center, cross-sectional study aimed to gather knowledge on this topic. Fifty-two patients with PASC recruited similar to 6 mo after ICU discharge were clustered based on their need for IMV (PASC + IMV, n = 27) or noninvasive support therapy (PASC + NIS, n = 25). Patients underwent pulmonary function and cardiopulmonary exercise testing (CPX) and were compared with a reference group (CONTROL, n = 19) comprising individuals of both sexes with similar age, comorbidities, and physical activity levels but without a history of COVID-19 illness. Individuals with PASC, irrespective of support therapy, presented with higher rates of cardiorespiratory abnormalities than CONTROL, especially dysfunctional breathing patterns, dynamic hyperinflation, reduced oxygen uptake and oxygen pulse, and blunted heart rate recovery (all P < 0.05). Only the rate of abnormal oxygen pulse was greater among PASC + IMV group than PASC + NIS group (P = 0.05). Mean estimates for all CPX variables were comparable between PASC + IMV and PASC + NIS groups (all P > 0.05). These findings indicate significant involvement of both central and peripheral factors, leading to exertional intolerance in individuals with PASC previously admitted to the ICU, regardless of their need for IMV. (AU)

Processo FAPESP: 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health
Beneficiário:Bruno Gualano
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 21/13580-1 - Efeitos de um programa de treinamento físico domiciliar sobre a qualidade de vida e parâmetros de saúde de pacientes sobreviventes à COVID-19 grave
Beneficiário:Igor Longobardi Amin
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 20/07540-4 - Efeitos do treinamento físico associado a suplementação proteica sobre os parâmetros ósseos em idosos obesos sarcopênicos em restrição calórica: um ensaio clínico controlado e randomizado
Beneficiário:Gersiel Nascimento de Oliveira Júnior
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 19/18039-7 - Reduzindo tempo sedentário em pacientes bariátricos: um estudo controlado e randomizado
Beneficiário:Karla Fabiana Goessler
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado