Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil October 2023: whole genome sequencing and phylogenetic analysis

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Araujo, Andreina de Carvalho ; Cho, Andrew Yong ; Silva, Laura Morais Nascimento ; Correa, Thais Camilo ; de Souza, Gabriela Cristini ; Albuquerque, Adriana Silva ; Macagnan, Eduardo ; Kolesnikvoas, Cristiane K. M. ; Meurer, Rafael ; Vieira, Jenyffer Vierheller ; Lemos, Giulia Gaglianone ; Barreto, Andre Silva ; Dick, Jeferson Luis ; Groch, Karina Rejane ; de Castilho, Pedro Volkmer ; Amgarten, Deyvid ; Malta, Fernanda ; Miller, Michael ; Dorlass, Erick G. ; Palameta, Soledad ; Lee, Sun-Hak ; Arns, Clarice Weis ; Durigon, Edison L. ; Pinho, Joao Renato R. ; Lee, Dong-Hun ; Ferreira, Helena Lage

• Tipo de documento: Artigo Científico
• Fonte: BMC Veterinary Research; v. 20, n. 1, p. 8-pg., 2024-07-02.

Resumo

Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts. (AU)

• Processo FAPESP: 23/08501-0 - Um programa de pesquisa conjunto entre a Coreia e o Brasil em doenças de alta relevância em animais, utilizando a influenza aviária como modelo
• Beneficiário: Helena Lage Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular