Graph network and symmetry analysis after combined XR and tDCS in stroke

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Carlos, Bruna M. ; Menezes, Lucas T. ; Rosa, Beatriz ; Furumoto, Bruna F. ; Feitosa, Saulo S. ; Fernandes, Corina A. ; Ferreira-Melo, Silvia E. ; Pereira, Julia D. ; Almeida, Sara ; Brandao, Alexandre F. ; Ruas, Cassio V. ; Castellano, Gabriela

• Tipo de documento: Artigo Científico
• Fonte: Biomedical Signal Processing and Control; v. 96, p. 9-pg., 2024-06-05.

Resumo

The integration of innovative neurotechnologies in rehabilitation programs seems promising for enhancing motor recovery in people with stroke. This study presents a comprehensive exploration of brain connectivity with symmetry and graph network analyses during motor rehabilitation using extended reality (XR) training and transcranial direct current stimulation (tDCS). The evolution of selected electroencephalography (EEG) features was assessed along with changes in clinical scores before and after the rehabilitation program in order to identify directions for future research. Clinical motor performance scales and resting -state EEG assessments showed trends indicating the improvement of connectivity and integration capacity over rehabilitation time, particularly within the theta, beta, and gamma frequency bands. Symmetry indices, particularly at higher frequencies, were significantly correlated with clinical improvements, demonstrating a stronger relationship between brain symmetry and lower extremity function as well as an increasing symmetry trend at the end of the rehabilitation program. Based upon the preliminary findings of this study, rehabilitation sessions that combine XR and tDCS can induce changes in neuroplasticity and improve motor recovery, which may in turn increase the life quality of people with stroke. (AU)

• Processo FAPESP: 15/03695-5 - Aplicação e desenvolvimento de ferramentas de realidade virtual para complementar a terapia convencional em pacientes com AVC e avaliação da recuperação utilizando conectividade cerebral por meio de fMRI
• Beneficiário: Alexandre Fonseca Brandão
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 20/16571-0 - Investigação de alterações cerebrais em pacientes neurológicos sujeitos a diferentes tratamentos de reabilitação
• Beneficiário: Bruna Mezzari Carlos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 22/08057-0 - Neuromodulação combinada a outras neurotecnologias para aplicação na reabilitação motora de pacientes de AVC
• Beneficiário: Cássio Víctora Ruas
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado