New 2-nitroimidazole-N-acylhydrazones, analogs of benznidazole, as anti-Trypanosoma cruzi agents

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Pitombeira, Marcelly C. S. R. ; Junior, Policarpo A. S. ; Murta, Silvane Maria Fonseca ; Romanha, Alvaro ; Luccas, Pedro H. ; Nonato, M. Cristina ; Rocha, Rafael E. O. ; Ferreira, Rafaela S. ; da Silveira, Flavia F. ; Castelo-Branco, Frederico S. ; Carvalho, Alcione S. ; Boechat, Nubia

• Tipo de documento: Artigo Científico
• Fonte: ARCHIV DER PHARMAZIE; v. 357, n. 7, p. 15-pg., 2024-04-16.

Resumo

Chagas disease is a neglected tropical parasitic disease caused by the protozoan Trypanosoma cruzi. Worldwide, an estimated 8 million people are infected with T. cruzi, causing more than 10,000 deaths per year. Currently, only two drugs, nifurtimox and benznidazole (BNZ), are approved for its treatment. However, both are ineffective during the chronic phase, show toxicity, and produce serious side effects. This work aimed to obtain and evaluate novel 2-nitroimidazole-N-acylhydrazone derivatives analogous to BNZ. The design of these compounds used the two important pharmacophoric subunits of the BNZ prototype, the 2-nitroimidazole nucleus and the benzene ring, and the bioisosterism among the amide group of BNZ and N-acylhydrazone. The 27 compounds were obtained by a three-step route in 57%-98% yields. The biological results demonstrated the potential of this new class of compounds, since eight compounds were potent and selective in the in vitro assay against T. cruzi amastigotes and trypomastigotes using a drug-susceptible strain of T. cruzi (Tulahuen) (IC50 = 4.3-6.25 mu M) and proved to be highly selective with low cytotoxicity on L929 cells. The type I nitroreductase (TcNTR) assay suggests that the new compounds may act as substrates for this enzyme. (AU)

• Processo FAPESP: 17/26679-0 - Derivados 4-quinolinonas como candidatos a fármacos antimaláricos: caracterização da atividade Antiplasmodial in vitro, in vivo e de modo de ação
• Beneficiário: Juliana Oliveira de Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/26196-7 - Nitrorredutase de Trypanosoma cruzi: busca por novos substratos e caracterização cinética
• Beneficiário: Pedro Henrique Luccas
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica