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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy

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Autor(es):
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Prado, Wagner L. [1] ; Oyama, Lila M. [2, 1] ; Lofrano-Prado, Mara C. [1] ; de Piano, Aline [1] ; Stella, Sergio G. [1] ; Nascimento, Claudia M. O. [1] ; Carnier, June [1] ; Caranti, Danielle A. [1] ; Tock, Lian [1] ; Tufik, Sergio [3] ; de Mello, Marco Tulio [1, 3] ; Damaso, Ana R. [2, 1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Paulista Med Sch, Nutr Postgrad Program, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil
[3] Univ Fed Sao Paulo, Paulista Med Sch, Dept Psychobiol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ADOLESCENT HEALTH; v. 49, n. 3, p. 300-305, SEP 2011.
Citações Web of Science: 5
Resumo

Objective: The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein {[}AgRP], neuropeptide Y {[}NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone {[}alpha-MSH]), in obese adolescents. Methods: A total of 88 adolescents (38 boys and 50 girls), including 62 obese and 26 normal-weight, aged 15-19 years were recruited. Obese adolescents were submitted to a 24-week multidisciplinary therapy. AgRP, NPY, melanin-concentrating hormone, leptin, insulin, glucose, alpha-MSH, total ghrelin, and food intake were measured at three stages (at baseline, after 12 weeks, and after 24 weeks). Results: At baseline, obese adolescents showed hyperleptinemia (circulating leptin levels, which were, in boys and girls, 40 and 35 times higher than in normal-weight subjects, respectively). After 24 weeks, these values decreased in all obese patients. Our results showed no differences in ghrelin levels between obese and normal-weight adolescents, in both genders. However, obese boys reduced their plasma ghrelin concentration after 24 weeks of therapy (p<.05). The multidisciplinary therapy decreased NPY and AgRP values and increased alpha-MSH; simultaneously with these changes there was a decrease in total food intake after 24 weeks of therapy. Conclusions: We can conclude that the multidisciplinary therapy was efficient to modulate neurohormonal control of food intake in obese adolescents. (C) 2011 Society for Adolescent Health and Medicine. All rights reserved. (AU)

Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular