| Texto completo | |
| Autor(es): |
Adami, Luana N. G.
;
Moyses-Oliveira, Mariana
;
Tufik, Sergio
;
Andersen, Monica L.
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | F&S SCIENCE; v. 5, n. 3, p. 7-pg., 2024-08-01. |
| Resumo | |
Objective: To study whether male factor infertility and insomnia share genetic risk variants and identify any molecular, cellular, and biologic interactions between these traits. Design: The in silico study was performed. Two lists of genetic variants were manually curated through a literature review, one of those associated with male factor infertility and the other with insomnia. Genes were assigned to these variants to compose male factor infertility-associated (454 genes) and insomnia-associated (921 genes) gene lists. Setting: Not applicable. Patient(s): Not applicable. Intervention(s): Not applicable. Main Outcome Measure(s): Enrichment of biologic pathways and protein-protein interaction analysis. Result(s): Twenty-eight genes were common to both lists, representing a greater overlap than would be expected by chance. In the 28 genes contained in the intersection list, there was a significant enrichment of pathways related to kinesin binding. A protein-protein interaction analysis using the intersection list as input retrieved 25 nodes and indicated that two of them were kinesin-related proteins (PLEKHM2 and KCL1). Conclusion(s): The shared male factor infertility and insomnia genes, and the biologic pathways highlighted in this study, suggest that further functional investigations into the interplay between fertility and sleep are warranted. (F S Sci (R) 2024;5:225-31. (c) 2024 by American Society for Reproductive Medicine.) (AU) | |
| Processo FAPESP: | 23/11995-5 - Distúrbios de sono, função sexual e fértil masculina: uma abordagem celular e molecular |
| Beneficiário: | Luana Nayara Gallego Adami |
| Modalidade de apoio: | Bolsas no Brasil - Programa Fixação de Jovens Doutores |
| Processo FAPESP: | 21/09089-0 - Edição genética em larga escala para o estudo de doenças do neurodesenvolvimento em modelos celulares isogênicos |
| Beneficiário: | Mariana Moysés Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 20/13467-8 - Relação da apneia obstrutiva do sono e suas comorbidades com a microbiota intestinal: interface com sexualidade e função reprodutiva |
| Beneficiário: | Monica Levy Andersen |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |