| Texto completo | |
| Autor(es): |
Silva, Michel Pablo dos Santos Ferreira
;
Ferreira, Maycon Junior
;
Shecaira, Tania Plens
;
Dias, Danielle da Silva
;
Kimura, Debora Conte
;
Irigoyen, Maria Claudia
;
Gomes, Guiomar Nascimento
;
De Angelis, Katia
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 19, n. 1, p. 16-pg., 2024-01-10. |
| Resumo | |
Objective In this study, we aimed to investigate the effects of the concurrent exercise training (CET) associated with the enalapril maleate on blood pressure variability (BPV) and renal profile in an experimental model of arterial hypertension (AH) and postmenopause.Methods Female ovariectomized spontaneously hypertensive rats (SHR) were distributed into 4 groups (n = 8/group): sedentary (SO), sedentary + enalapril (SOE), trained (TO) and trained + enalapril (TOE). Both enalapril (3mg/kg) and CET (3 days/week) were conducted during 8 weeks. Blood pressure (BP) was directly recorded for BPV analyses. Renal function, morphology, inflammation and oxidative stress were assessed.Results The SOE, TO e TOE groups presented decreased systolic BP compared with SO. Both trained groups (TO and TOE) presented lower BPV and increased baroreflex sensitivity (TO: 0.76 +/- 0.20 and TOE: 1.02 +/- 0.40 vs. SO: 0.40 +/- 0.07 ms/mmHg) compared with SO group, with additional improvements in TOE group. Creatinine and IL-6 levels were reduced in SOE, TO and TOE compared with SO group, while IL-10 was increased only in TOE group (vs. SO). Enalapril combined with CET promote reduction in lipoperoxidation (TOE: 1.37 +/- 0.26 vs. SO: 2.08 +/- 0.48 and SOE: 1.84 +/- 0.35 mu mol/mg protein) and hydrogen peroxide (TOE: 1.89 +/- 0.40 vs. SO: 3.70 +/- 0.19 and SOE: 2.73 +/- 0.70 mu M), as well as increase in catalase activity (vs. sedentary groups). The tubulointerstitial injury was lower in interventions groups (SOE, TO and TOE vs. SO), with potentialized benefits in the trained groups.Conclusions Enalapril combined with CET attenuated BPV and baroreflex dysfunctions, probably impacting on end-organ damage, as demonstrated by attenuation in the AH-induced renal inflammations, oxidative stress and morphofunctional impairments in postmenopausal rats. (AU) | |
| Processo FAPESP: | 19/06277-0 - Efeitos do treinamento físico combinado associado ao tratamento farmacológico nas adaptações neuroimunes em modelo experimental de Hipertensão e menopausa: papel do barorreflexo |
| Beneficiário: | Maycon Junior Ferreira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |