| Texto completo | |
| Autor(es): Mostrar menos - |
Souza, Luana Lelis
;
Dominguez-Castano, Pablo
;
Gianvecchio, Sarah Bernardes
;
Sakamoto, Leandro Sannomiya
;
Rodrigues, Gustavo Roberto Dias
;
Soares, Tainara Luana da Silva
;
Bonilha, Sarah Figueiredo Martins
;
Marcatto, Juliana de Oliveira Santos
;
Albuquerque, Lucia Galvao
;
Silva, Josineudson Augusto I. I. Vasconcelos
;
Mercadante, Maria Eugenia Zerlotti
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ANIMAL SCIENCE; v. 102, p. 10-pg., 2024-07-27. |
| Resumo | |
The objectives of the present study were to estimate the heritability for daily methane emission (CH4 ) and residual daily methane emission (CH4 (res)) in Nellore cattle, as well as to perform genome-wide association studies (GWAS) to identify genomic regions and candidate genes influencing the genetic variation of CH4 and CH4 (res.). Methane emission phenotypes of 743 Nellore animals belonging to 3 breeding programs were evaluated. CH4 was measured using the sulfur hexafluoride (SF6) tracer technique (which involves an SF6 permeation tube introduced into the rumen, and an appropriate apparatus on each animal), and CH4res was obtained as the difference between observed CH4 and CH4 adjusted for dry matter intake. A total of 6,252 genotyped individuals were used for genomic analyses. Data were analyzed with a univariate animal model by the single-step GBLUP method using the average information restricted maximum likelihood (AIREML) algorithm. The effects of single nucleotide polymorphisms (SNPs) were obtained using a single-step GWAS approach. Candidate genes were identified based on genomic windows associated with quantitative trait loci (QTLs) related to the 2 traits. Annotation of QTLs and identification of candidate genes were based on the initial and final coordinates of each genomic window considering the bovine genome ARS-UCD1.2 assembly. Heritability estimates were of moderate to high magnitude, being 0.42 +/- 0.09 for CH4 and 0.21 +/- 0.09 for CH4 (res), indicating that these traits will respond rapidly to genetic selection. GWAS revealed 11 and 15 SNPs that were significantly associated (P < 10(-6)) with genetic variation of CH4 and CH4 res, respectively. QTLs associated with feed efficiency, residual feed intake, body weight, and height overlapped with significant markers for the traits evaluated. Ten candidate genes were present in the regions of significant SNPs; 3 were associated withCH(4) and 7 with CH4 (res.) The identified genes are related to different functions such as modulation of the rumen microbiota, fatty acid production, and lipid metabolism. CH4 and CH4 (res) presented sufficient genetic variation and may respond rapidly to selection. Therefore, these traits can be included in animal breeding programs aimed at reducing enteric methane emissions across generations. (AU) | |
| Processo FAPESP: | 17/10630-2 - Aspectos genéticos da qualidade, eficiência e sustentabilidade da produção de carne em animais da raça Nelore |
| Beneficiário: | Lucia Galvão de Albuquerque |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/20026-8 - EMU concedido no processo 2017/10630-2: servidor |
| Beneficiário: | Lucia Galvão de Albuquerque |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 23/11176-4 - Mapeamento de candidatos a haplótipos letais e regiões genômicas associadas a ocorrência de aborto e mortalidade pré-desmame em bovinos da raça Nelore |
| Beneficiário: | Gustavo Roberto Dias Rodrigues |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 17/50339-5 - Plano de desenvolvimento institucional de pesquisa do Instituto de Zootecnia (PDIp) |
| Beneficiário: | Lenira El Faro Zadra |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Modernização de Institutos Estaduais de Pesquisa |
| Processo FAPESP: | 18/17313-5 - Emissão de metano entérico, eficiência alimentar e digestibilidade de bovinos da raça Nelore |
| Beneficiário: | Leandro Sannomiya Sakamoto |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/11738-7 - Correlações fenotípicas, genéticas e associação genômica ampla entre eficiência alimentar e emissão de metano entérico de bovinos Nelore |
| Beneficiário: | Luana Lelis Souza |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |