| Texto completo | |
| Autor(es): Mostrar menos - |
Braga, Carolyne B.
;
Perli, Gabriel
;
Wang, Qi
;
Wylie, Luke
;
Bertuzzi, Diego L.
;
Soares, Marco C. P.
;
Ramos, Miguel D.
;
Ruiz, Jaime
;
Padua, Agilio
;
Astruc, Didier
;
Ornelas, Catia
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ADVANCED HEALTHCARE MATERIALS; v. N/A, p. 17-pg., 2024-09-15. |
| Resumo | |
Dendrimers and supramolecular chemistry continue to fascinate researchers due to the endless unrevealed potential of their combination. This study investigates the self-assembly process of a series of hydrophobic triazolylferrocenyl dendrimers in aqueous medium. Deep investigation through NMR spectroscopy, absorption UV-vis spectroscopy along with theoretical simulations demonstrates that the ferrocenyl moieties interact intramolecularly and intermolecularly driving the self-assembly process. Data obtained by DLS, NTA, SEM, TEM, and EF-TEM demonstrate that these dendrimers, in water, spontaneously self-assemble through a hierarchical process. The dendrimers first self-assemble into uniform nanovesicles, which in turn self-assemble into larger vesosomes. The resulting vesosomes emit green non-traditional intrinsic fluorescence, which is a property that emerged from the self-assembled architectures. The vesosomes are efficiently uptaken by cancer cells and induce significant cytotoxic activity against the cancer cell line MCF-7, up to the submicromolar concentration. Positive dendritic effects are identified in the fluorescence intensity and in the cytotoxic activity of the vesosomes, which follow the trend G0-9Fc < G1-27Fc < G2-81Fc. This work showcases the remarkable potential of combining the two dynamic fields of dendrimers and supramolecular chemistry, which resulted in green fluorescent vesosomes capable of performing the dual role of cell imaging and killing, with potential applications in nanotheranostics. (AU) | |
| Processo FAPESP: | 08/57906-3 - Instituto Nacional de Fotônica Aplicada à Biologia Celular - INFABIC |
| Beneficiário: | Hernandes Faustino de Carvalho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/24488-3 - Desenvolvimento de Carregadores Nanoestruturados Baseados em Polisacarídeos para Entrega Controlada de Antibióticos e Nanopartículas de Prata |
| Beneficiário: | Gabriel Perli |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 17/06146-8 - Desenvolvimento de nanocarregadores baseados em dendrímeros e nanopartículas poliméricas para a vetorização seletiva da goniotalamina, piplartina e monastrol |
| Beneficiário: | Carolyne Brustolin Braga |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/02093-0 - Desenvolvimento de novos nanomateriais para aplicações em nanomedicina |
| Beneficiário: | Cátia Cristina Capêlo Ornelas Megiatto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/00555-9 - Desenvolvimento de nanopartículas poliméricas e dendrímeros multifuncionais para vetorização de fármacos |
| Beneficiário: | Igor Dias Jurberg |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |