| Texto completo | |
| Autor(es): |
Vaz, Camila de Oliveira
;
Jacintho, Bruna Cardoso
;
Santos, Gabrielle de Mello
;
de Oliveira, Jose Diogo
;
Mazetto, Bruna Moraes
;
Geraldo, Murilo Vieira
;
Orsi, Fernanda A.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Lupus; v. 33, n. 13, p. 11-pg., 2024-09-27. |
| Resumo | |
Background Antiphospholipid syndrome (APS) is an acquired autoimmune disorder characterized by distinct pathophysiological mechanisms leading to heterogeneous manifestations, including venous and arterial thrombosis. Despite the lack of specific markers of thrombosis risk in APS, some of the mechanisms responsible for thrombosis in APS may overlap with those of other thromboembolic diseases. Understanding these similarities is important for improving the assessment of thrombosis risk in APS. MicroRNAs (MiRNAs) are RNA molecules that regulate gene expression and may influence the autoimmune response and coagulation.Purpose In this scoping review we aimed to investigate shared miRNAs profiles associated with APS and other thromboembolic diseases as a means of identifying markers indicative of a pro-thrombotic profile among patients with APS.Data collection and Results Through a comprehensive search of scientific databases, 45 relevant studies were identified out of 1020 references. miRs-124-3p, 125b-5p, 125a-5p, and 17-5p, were associated with APS and arterial thrombosis, while miRs-106a-5p, 146b-5p, 15a-5p, 222-3p, and 451a were associated with APS and venous thrombosis. Additionally, miR-126a-3p was associated with APS and both arterial and venous thrombosis.Conclusion We observed that APS shares a common miRNAs signature with non-APS related thrombosis, suggesting that miRNA expression profiles may serve as markers of thrombotic risk in APS. Further validation of a pro-thrombotic miRNA signature in APS is warranted to improve risk assessment, diagnosis, and management of APS. (AU) | |
| Processo FAPESP: | 20/12630-2 - Contribuição das redes extracelulares de neutrófilos (NETs) e da ativação plaquetária para a imunotrombose na COVID-19 e efeito inibitório de substâncias que aumentam os níveis intracelulares dos nucleotídeos cíclicos |
| Beneficiário: | Fernanda Loureiro de Andrade Orsi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/07922-4 - Derivação e validação de painel de miRNAs circulantes como marcadores de formas graves da COVID-19 |
| Beneficiário: | Camila de Oliveira Vaz |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |