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Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis

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Autor(es):
Tasso, Camilla Olga ; Ferrisse, Tulio Morandin ; Oliveira, Analu Barros de ; Ribas, Beatriz Ribeiro ; Jorge, Janaina Habib
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: CANCER EPIDEMIOLOGY; v. 86, p. 9-pg., 2023-10-01.
Resumo

Oral squamous cell carcinoma (OSCC) is considered a multifactorial disease and has been associated with microbial infections, although the association with Candida spp. is still controversial. This systematic review focused on clinical trials which evaluated the relation between oral Candida spp colonization and OSCC. PubMed; Scopus; Embase; Web of Science and Scientific Direct were assessed. Independent reviewers conducted the diagram steps. For data extraction the PRISMA protocol was followed. The quality analysis of case-control studies was performed based on the Newcastle-Ottawa scale. Meta-analysis was performed to evaluate the frequency of Candida spp and the levels of microbial acetaldehyde production (MAP) being odds ratio (OR) the effect-measure applied. Eight and six studies were included in the qualitative analysis and meta-analysis, respectively. It was noted that there was a significantly higher frequency of Candida species (p = 0.0003/OR = 9.50) in patients diagnosed with OSCC than healthy patients, especially Candida krusei (p = 0.0167/OR=4.62). Candida spp., from oral cancer patients demonstrated significantly greater biofilm, biofilm metabolic activity, phospholipase, proteinase activity and a higher production of MAP (p = 0.0111/OR = 2.67). Candida species may have a potential role in OSCC development. Further studies should be conducted to elucidate the mechanism of action of Candida spp and others risk factors in the development of OSCC. (AU)

Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
Beneficiário:Vanderlei Salvador Bagnato
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 21/01191-0 - Indução de tolerância e caracterização do biofime de Candida albicans submetido à terapia fotodinâmica antimicrobiana
Beneficiário:Túlio Morandin Ferrisse
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 22/12828-2 - Interação do biofilme multiespécie de Candida streptococcus na desmineralização dentária e na candidose oral
Beneficiário:Túlio Morandin Ferrisse
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 20/07110-0 - Potencial da terapia fotodinâmica na modulação da resposta inflamatória e nos fatores de virulência microbianos: avaliação em modelo de co-culturas tridimensionais de fibroblastos gengivais, Candida albicans e Staphylococcus aureus
Beneficiário:Analú Barros de Oliveira
Modalidade de apoio: Bolsas no Brasil - Doutorado