| Texto completo | |
| Autor(es): |
Guerra, Marina Bertoni
;
Santana, Kelly Gomes
;
Momolli, Marcos
;
Labat, Rodrigo
;
Chavantes, Maria Cristina
;
Zammuner, Stella Regina
;
Silva Junior, Jose Antonio
;
da Palma, Renata Kelly
;
Aimbire, Flavio
;
de Oliveira, Ana Paula Ligeiro
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Biophotonics; v. N/A, p. 9-pg., 2024-08-12. |
| Resumo | |
The objective of the study was to evaluate the effect of photobiomodulation (PBM) with laser on the inflammatory process in an experimental in vitro model of ACO. The groups were: (1) human bronchial epithelial cells (BEAS-2B); (2) BEAS-2B cells treated with dexamethasone; (3) BEAS-2B cells irradiated with laser; (4) BEAS-2B cells stimulated with cigarette smoke extract (CSE) + House Dust Mite (HDM); (5) BEAS-2B cells stimulated with CSE + HDM and treated with dexamethasone; (6) BEAS-2B cells incubated with CSE + HDM and irradiated with laser. After 24 h, cytokines were quantified. There was a reduction in TNF-alpha, IL-1 beta, IL-6, IL-4, IL-5, IL-13, IL-17, IL-21, IL-23, and an increase in IL-10 and IFN-gamma in cells from the laser-irradiated ACO group compared to only ACO group. With these results, we can suggest that photobiomodulation acts in the modulation of inflammation observed in ACO, and may be a treatment option. Human bronchial epithelial cells (BEAS-2B) were stimulated with cigarette smoke extract (CSE) and house dust mite (HDM) for induction of the asthma-COPD overlap (ACO). There was an increase in the secretion of inflammatory cytokines in the ACO group. Following photobiomodulation therapy (FBM), a reduction in inflammation was demonstrated with a decrease in the concentration of inflammatory cytokines and increase in IL-10 and IFN-gamma. image (AU) | |
| Processo FAPESP: | 12/16498-5 - Efeito da terapia com laser de baixa potência (LBP) em modelos experimentais de doenças pulmonares crônicas |
| Beneficiário: | Ana Paula Ligeiro de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |