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Sustained hypoxia in mice increases parasympathetic but not sympathetic tone

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Autor(es):
Souza, Juliana R. ; de Oliveira, Mauro ; Machado, Benedito H.
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: CURRENT RESEARCH IN PHYSIOLOGY; v. 5, p. 8-pg., 2022-01-01.
Resumo

The autonomic profile of mice submitted to sustained hypoxia (SH) was not yet fully evaluated. Herein, we characterized the cardiovascular and autonomic profile of conscious freely moving mice submitted to SH using two sequential experimental protocols to evaluate the parasympathetic and sympathetic tone to the heart and the sympathetic tone to the vascular resistance. In the first protocol the sequence of antagonists was methyl-atropine followed by propranolol and then by prazosin, while in the second protocol the sequence was propranolol followed by methyl-atropine and then by prazosin. In SH the baseline heart rate was significantly lower than in control mice and the antagonism of the parasympathetic and sympathetic tone to the heart in both experimental protocols indicated an increased parasympathetic tone in SH mice and no changes in the sympathetic tone. Antagonism of the sympathetic tone to the vascular resistance with prazosin produced similar changes in arterial pressure in control and SH mice. Altogether these findings support the concept that mice submitted to SH present a significant increase in the parasympathetic but not in the sympathetic tone, which may explain why the baseline arterial pressure was not increased in SH mice. (AU)

Processo FAPESP: 19/21916-0 - Caracterização das alterações cardiovasculares e respiratórias de camundongos previamente submetidos à hipóxia mantida
Beneficiário:Juliana Reis Souza
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 18/15957-2 - Modulação astrocítica dos neurônios bulbares envolvidos com a geração e controle das atividades simpática e respiratória de roedores submetidos à hipóxia
Beneficiário:Benedito Honorio Machado
Modalidade de apoio: Auxílio à Pesquisa - Temático