Lack of progression of brain abnormalities in first-episode psychosis: a longitudinal magnetic resonance imaging study

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Schaufelberger, M. S. ^[1] ; Lappin, J. M. ; Duran, F. L. S. ; Rosa, P. G. P. ; Uchida, R. R. ; Santos, L. C. ; Murray, R. M. ; McGuire, P. K. ; Scazufca, M. ; Menezes, P. R. ; Busatto, G. F.

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Psychiat Neuroimaging LIM 21, Dept & Inst Psychiat, Fac Med, Ctr Med Nucl, Hosp Clin FMUSP, BR-05403010 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PSYCHOLOGICAL MEDICINE; v. 41, n. 8, p. 1677-1689, AUG 2011.
• Citações Web of Science: 35

Resumo

Background. Some neuroimaging studies have supported the hypothesis of progressive brain changes after a first episode of psychosis. We aimed to determine whether (i) first-episode psychosis patients would exhibit more pronounced brain volumetric changes than controls over time and (ii) illness course/treatment would relate to those changes. Method. Longitudinal regional grey matter volume and ventricle : brain ratio differences between 39 patients with first-episode psychosis (including schizophrenia and schizophreniform disorder) and 52 non-psychotic controls enrolled in a population-based case-control study. Results. While there was no longitudinal difference in ventricle : brain ratios between first-episode psychosis subjects and controls, patients exhibited grey matter volume changes, indicating a reversible course in the superior temporal cortex and hippocampus compared with controls. A remitting course was related to reversal of baseline temporal grey matter deficits. Conclusions. Our findings do not support the hypothesis of brain changes indicating a progressive course in the initial phase of psychosis. Rather, some brain volume abnormalities may be reversible, possibly associated with a better illness course. (AU)

• Processo FAPESP: 03/13627-0 - Seguimento de pacientes portadores de psicoses funcionais um ano após o primeiro contato com serviços de saúde: prognóstico, aspectos de neuroimagem, uso de serviços e sobrecarga em cuidadores informais
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular