| Texto completo | |
| Autor(es): |
Cuin, Alexandre
[1]
;
Massabni, Antonio Carlos
[2]
;
Pereira, Guilherme Alves
[1]
;
Fujimura Leite, Clarice Queico
[3]
;
Pavan, Fernando Rogerio
[3]
;
Sesti-Costa, Renata
[4]
;
Heinrich, Tassiele Andrea
[4]
;
Costa-Neto, Claudio M.
[4]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] UFJF, Inst Ciencias Exatas, Dept Quim, Juiz De Fora, MG - Brazil
[2] Univ Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, Sao Paulo - Brazil
[3] UNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, Araraquara, SP - Brazil
[4] USP, Fac Med, Dept Bioquim & Imunol, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOMEDICINE & PHARMACOTHERAPY; v. 65, n. 5, p. 334-338, AUG 2011. |
| Citações Web of Science: | 25 |
| Resumo | |
Synthesis, characterization and biological studies of silver and gold complexes with 6-mercaptopurine (H2MP) are described. The Ag(I) and Au(I) complexes with HMP-, AgHMP and AuIHMP, were obtained by mixing an acidified H2MP aqueous solution with an equimolar aqueous solution of AgNO3 or Au(CN)2. The Au(III) complex with HMP-, AuIIIHMP, was obtained by adding an aqueous solution of K(AuCl4) to an acidified H2MP aqueous solution (1: 1 molar ratio) and the final solution was acidified with HCl to pH = 1.0. The Au(III) MP complex, KAu(MP)2, was obtained by adding an aqueous solution of K(AuCl4) to a basic H2MP solution (M: L - 1: 2 molar ratio). Formulas for the complexes are: (Ag{[}C5H3N4S]){*}H2O for AgHMP, (Au{[}C5H3N4S]) for AuIHMP, (Au{[}C5H3N4S]{[}Cl]2){*}2H2O for AuIIIHMP and K(Au{[}C5H2N4S]2)center dot 2H2O for KAu(MP) 2. The AuIHMP and KAu(MP) 2 complexes decreased cell viability of HeLa cancer cells in vitro. The IC50 values for AuIHMP and KAu(MP) 2 are 3.0 and 30.0 mu M, respectively. Anti-M. tuberculosis assays showed a MIC value of 2.24 mu M for AuIHMP and 5.12 mu M for free MP while AgHMP is active at the concentration 93.2 mu M. (C) 2011 Elsevier Masson SAS. All rights reserved. (AU) | |
| Processo FAPESP: | 06/58923-3 - Síntese, caracterização estrutural e atividade biológica de complexos de ouro e prata com ligantes sulfurados |
| Beneficiário: | Alexandre Cuin |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 07/55851-4 - Síntese, caracterização estrutural e atividade biológica de complexos de ouro e prata com ligantes sulfurados |
| Beneficiário: | Antonio Carlos Massabni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |