| Texto completo | |
| Autor(es): |
Oliveira, Luiz M.
;
Moreira, Thiago S.
;
Takakura, Ana C.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Respiratory Physiology & Neurobiology; v. 320, p. 9-pg., 2023-12-14. |
| Resumo | |
Respiration is regulated by various types of neurons located in the pontine-medullary regions. The Ko center dot lliker-Fuse (KF)/A7 noradrenergic neurons play a role in modulating the inspiratory cycle by influencing the respiratory output. These neurons are interconnected and may also project to brainstem and spinal cord, potentially involved in regulating the post -inspiratory phase. In the present study, we hypothesize that the parafacial (pF) neurons, in conjunction with adrenergic mechanisms originating from the KF/A7 region, may provide the neurophysiological basis for breathing modulation. We conducted experiments using urethane -anesthetized, vagotomized, and artificially ventilated male Wistar rats. Injection of L -glutamate into the KF/A7 region resulted in inhibition of inspiratory activity, and a prolonged and high -amplitude genioglossal activity (GGEMG). Blockade of the alpha 1 adrenergic receptors (alpha 1-AR) or the ionotropic glutamatergic receptors in the pF region decrease the activity of the GGEMG without affecting inspiratory cessation. In contrast, blockade of alpha 2-AR in the pF region extended the duration of GG activity. Notably, the inspiratory and GGEMG activities induced by KF/A7 stimulation were completely blocked by bilateral blockade of glutamatergic receptors in the Bo center dot tzinger complex (Bo center dot tC). While our study found a limited role for alpha 1 and alpha 2 adrenergic receptors at the pF level in modulating the breathing response to KF/A7 stimulation, it became evident that Bo center dot tC neurons are responsible for the respiratory effects induced by KF/A7 stimulation. (AU) | |
| Processo FAPESP: | 15/18842-3 - Mecanismos orexinérgicos e aminérgicos no controle respiratório em modelo animal de Doença de Parkinson |
| Beneficiário: | Luiz Marcelo Oliveira Santos |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 19/01236-4 - Efeitos de tratamentos farmacológicos e não farmacológicos nas alterações respiratórias observadas em um modelo murino da Doença de Parkinson |
| Beneficiário: | Ana Carolina Takakura Moreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/23376-1 - Núcleo retrotrapezóide, quimiossensibilidade central e automaticidade respiratória |
| Beneficiário: | Thiago dos Santos Moreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/09323-3 - Regulação do fluxo sanguíneo na superfície ventrolateral do bulbo em modelo animal de Doença de Parkinson |
| Beneficiário: | Luiz Marcelo Oliveira Santos |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |