| Texto completo | |
| Autor(es): |
Dias, Barbara K. M.
;
Mohanty, Abhinab
;
Garcia, Celia R. S.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 25, n. 14, p. 13-pg., 2024-07-01. |
| Resumo | |
Plasmodium, a digenetic parasite, requires a host and a vector for its life cycle completion. Most Plasmodium species display circadian rhythmicity during their intraerythrocytic cycle within the host, aiding in immune evasion. This rhythmicity, however, diminishes in in vitro cultures, highlighting the importance of host-derived signals for synchronizing the parasite's asexual cycle. Studies indicate a species-specific internal clock in Plasmodium, dependent on these host signals. Melatonin, a hormone the pineal gland produces under circadian regulation, impacts various physiological functions and is extensively reviewed as the primary circadian marker affecting parasite rhythms. Research suggests that melatonin facilitates synchronization through the PLC-IP3 signaling pathway, activating phospholipase C, which triggers intracellular calcium release and gene expression modulation. This evidence strongly supports the role of melatonin as a key circadian marker for parasite synchronization, presenting new possibilities for targeting the melatonin pathway when developing novel therapeutic approaches. (AU) | |
| Processo FAPESP: | 22/15522-1 - Vias de sinalização e função dos receptores serpentinos SR1 e SR10 de Plasmodium falciparum |
| Beneficiário: | Barbara Karina de Menezes Dias |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/07177-7 - EMU concedido no processo 2011/51295-5: image system |
| Beneficiário: | Célia Regina da Silva Garcia |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 17/08684-7 - Decodificar aspectos da biologia celular e molecular do Plasmodium como uma ferramenta para desenvolver novos antimaláricos |
| Beneficiário: | Célia Regina da Silva Garcia |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |