| Texto completo | |
| Autor(es): Mostrar menos - |
de Souza, Lucas Lacerda
;
Fonseca, Felipe Paiva
;
de Caceres, Cinthia Veronica Bardalez Lopez
;
Soares, Ciro Dantas
;
Gurgel, Alberto da Costa
;
Pontes, Helder Antonio Rebelo
;
Pontes, Flavia Sirotheau Correa
;
Paradela, Carolina Almeida
;
Correia-Neto, Ivan Jose
;
Kalinin, Yuri
;
Lopes, Marcio Ajudarte
;
Santos-Silva, Alan Roger
;
de Almeida, Oslei Paes
;
Vargas, Pablo Agustin
;
Robinson, Liam
;
van-Heerden, Willie F. P.
Número total de Autores: 16
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL; v. 29, n. 6, p. 8-pg., 2024-11-01. |
| Resumo | |
Background: This study aimed to explore the clinical, histopathologic, and immunohistochemical characteristics of myofibromas (MFs) affecting the head and neck region. Material and Methods: Formalin-fixed paraffin-embedded tissue blocks of patients diagnosed with MFs in the head and neck were retrieved from the archives of three oral and maxillofacial pathology laboratories. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed, and followup status were retrieved from the patient's medical records or pathology reports. Results: Sixteen cases were included in the study. Females were slightly more affected than males. The first and second decades of life were more prevalent. The most common locations were the alveolar ridge and cheek. Although rare, some of the patients were presented with intraosseous lesions. Microscopically, tumors consisted of plump, spindle-shaped myofibroblasts arranged in whorls or fascicles with varying degrees of differentiation. Immunohistochemically, diffuse positivity for vimentin and alpha-SMA was observed, while Ki-67 mostly showed low immunoreactivity (<5%). Treatment primarily involved complete excision. Conclusions: MFs in the head and neck region are rare and predominantly affect female patients during the second decade of life. Despite their rarity, central MFs should be considered in the differential diagnosis of intraosseous lesions in infants. (AU) | |
| Processo FAPESP: | 22/03123-5 - Inteligência artificial no diagnóstico de neoplasias de células pequenas, redondas e azuis |
| Beneficiário: | Lucas Lacerda de Souza |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 20/03818-8 - Estudo clinicopatológico, molecular e prognóstico das neoplasias miofibroblásticas orais |
| Beneficiário: | Oslei Paes de Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |