| Texto completo | |
| Autor(es): |
Goncalves, Daniela Caetano
;
Gomes, Silvio Pires
;
Seelaender, Marilia
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 25, n. 22, p. 11-pg., 2024-11-01. |
| Resumo | |
Cancer-associated cachexia (CAC) is a severe wasting syndrome, marked by involuntary weight loss and muscle wasting. It is a leading cause of cancer-related morbidity and mortality, and is driven by systemic, chronic low-grade inflammation. Key cytokines, such as IL-6 and GDF15, activate catabolic pathways in many organs. This study examined the role of inflammation and metabolic disruption in the liver during CAC, focusing on its dual role as both a target and a source of inflammatory factors. The analysis covered protein and lipid metabolism disturbances, including the hepatic production of acute-phase proteins and insulin resistance. Hepatic inflammation contributes to systemic dysfunction in CAC. The increased production of C-Reactive Protein (CRP) impacts muscle wasting, while liver inflammation leads to insulin resistance and hepatic steatosis, aggravating the cachectic state. Therefore, understanding the molecular mechanisms of liver metabolism in CAC is essential for developing effective therapies. Potential interventions include anti-inflammatory treatments, anabolic strategies, and restoration of lipid metabolism. Further research is necessary to explore the liver's full contribution to CAC and its systemic effects, allowing to the development of liver-targeted therapeutic strategies. (AU) | |
| Processo FAPESP: | 20/07765-6 - Tempestade de citocinas no paciente de covid-19: contribuição do tecido adiposo |
| Beneficiário: | Marilia Cerqueira Leite Seelaender |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional |
| Beneficiário: | Marilia Cerqueira Leite Seelaender |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/19988-2 - Suplementação de farinha de semente de uva em pacientes com caquexia associada ao câncer colorretal em período perioperatório como estratégia para atenuação da perda de peso e massa muscular |
| Beneficiário: | Daniela Caetano Gonçalves |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |