Clinical complications in envenoming by Apis honeybee stings: insights into mechanisms, diagnosis, and pharmacological interventions

Autor(es)

Cavalcante, Joeliton S. ; Riciopo, Pedro Marques ; Pereira, Ana Flavia Marques ; Jeronimo, Bruna Cristina ; Angstmam, Davi Gomes ; Possas, Felipe Carvalhaes ; de Andrade Filho, Adebal ; Cerni, Felipe A. ; Pucca, Manuela B. ; Ferreira Junior, Rui Seabra

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 15, p. 18-pg., 2024-09-18.

Resumo

Envenoming resulting from Apis honeybee stings pose a neglected public health concern, with clinical complications ranging from mild local reactions to severe systemic manifestations. This review explores the mechanisms underlying envenoming by honeybee sting, discusses diagnostic approaches, and reviews current pharmacological interventions. This section explores the diverse clinical presentations of honeybee envenoming, including allergic and non-allergic reactions, emphasizing the need for accurate diagnosis to guide appropriate medical management. Mechanistic insights into the honeybee venom's impact on physiological systems, including the immune and cardiovascular systems, are provided to enhance understanding of the complexities of honeybee sting envenoming. Additionally, the article evaluates emerging diagnostic technologies and therapeutic strategies, providing a critical analysis of their potential contributions to improved patient outcomes. This article aims to provide current knowledge for healthcare professionals to effectively manage honeybee sting envenoming, thereby improving patient care and treatment outcomes. (AU)

• Processo FAPESP: 23/01554-1 - Atividade antibacteriana e antiviral da melitina e seu impacto sobre perfil proteômico de Acinetobacter baumannii, Enterococcus faecium, Klebsiella pneumoniae, Zika Vírus e SARS-CoV-2
• Beneficiário: Rui Seabra Ferreira Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 23/09921-3 - Atividade antibacteriana e antiviral da melitina e seu impacto sobre perfil proteômico de Acinetobacter baumannii, Enterococcus faecium, Klebsiella pneumoniae, Zika vírus e SARS-CoV-2
• Beneficiário: Ana Flávia Marques Pereira
• Modalidade de apoio: Bolsas no Brasil - Programa Fixação de Jovens Doutores
• Processo FAPESP: 21/11936-3 - Centro de Ciência Translacional e Desenvolvimento de Biofármacos
• Beneficiário: Benedito Barraviera
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Ciência para o Desenvolvimento
• Processo FAPESP: 22/16060-1 - Dos mecanismos aos biomarcadores de envenenamento por serpentes brasileiras: um estudo multicêntrico para o desenvolvimento de estratégias em diagnóstico e monitoramento
• Beneficiário: Joeliton dos Santos Cavalcante
• Modalidade de apoio: Bolsas no Brasil - Doutorado