Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain

Autor(es)

Alves-Silva, Thais ; Hungaro, Talita G. R. ; Freitas-Lima, Leandro C. ; Arthur, Gabriel de Melo ; Arruda, Adriano C. ; Santos, Raisa B. ; Oyama, Lila M. ; Mori, Marcelo A. S. ; Bader, Michael ; Araujo, Ronaldo C.

• Tipo de documento: Artigo Científico
• Fonte: ISCIENCE; v. 26, n. 12, p. 19-pg., 2023-11-18.

Resumo

Given the importance of the kinin B1 receptor in insulin and leptin hormonal regulation, which in turn is crucial in maternal adaptations to ensure nutrient supply to the fetus, we investigated the role of this receptor in maternal metabolism and fetoplacental development. Wild-type and kinin B1 receptor-deficient (B1KO) female mice were mated with male mice of the opposite genotype. Consequently, the entire litter was heterozygous for kinin B1 receptor, ensuring that there would be no influence of offspring genotype on the maternal phenotype. Maternal kinin B1 receptor blockade reduces adiponectin secretion by adipose tissue ex vivo , consistent with lower adiponectin levels in pregnant B1KO mice. Furthermore, fasting insulinemia also increased, which was associated with placental insulin resistance, reduced placental glycogen accumulation, and heavier offspring. Therefore, we propose the combination of chronic hyperinsulinemia and reduced adiponectin secretion in B1KO female mice create a maternal obesogenic environment that results in heavier pups. (AU)

• Processo FAPESP: 15/20082-7 - Sistema calicreína cininas no exercício físico e metabolismo
• Beneficiário: Ronaldo de Carvalho Araújo
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/08354-2 - A ação recíproca do sistema imune e do metabolismo como principal determinante do processo de envelhecimento
• Beneficiário: Marcelo Alves da Silva Mori
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/21368-7 - Papel do receptor B1 de cininas no metabolismo materno induzido pelo treinamento físico durante a gravidez
• Beneficiário: Thaís Alves da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto