In vivo anti-inflammatory activity of BACCHARIN from BRAZILIAN green PROPOLIS

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Almeida-Junior, Silvio ; de Oliveira, Katia Roberta Prieto ; Marques, Lais Prado ; Martins, Joa Guilherme ; Ubeda, Heloisa ; Santos, Mario Ferreira Conceica ; Rodrigues, Marcela Aldrovani ; Andrade e Silva, Marcio Luis ; Ambrosio, Sergio Ricardo ; Bastos, Jairo Kenupp ; Ross, Samir A. ; Furtado, Ricardo Andrade

• Tipo de documento: Artigo Científico
• Fonte: Fitoterapia; v. 175, p. 8-pg., 2024-05-01.

Resumo

Baccharin is one of the major compounds found in Brazilian green propolis and its botanical source, Baccharis dracunculifolia. Considering the biological effects of propolis and B. dracunculifolia, this study aims to evaluate the analgesic and anti-inflammatory potential of baccharin. The neurodepressor potential was performed by the open field test, analgesia by mechanical stimulation with Dynamic Plantar Aesthesiometer, and by thermal stimulation with Hargreaves apparatus. In addition, the anti-inflammatory potential was achieved by the paw edema assay, histopathological evaluation, and NF-kB expression. Doses of 2.5, 5, and 10 mg/kg of baccharin were evaluated. After euthanasia, plantar tissue was collected and prepared for histology. As a result, analgesic activity was observed at a dose of 10 mg/kg of baccharin in thermal stimulation under an inflammatory process and anti-inflammatory potential at a dose of 5 mg/kg of baccharin from the second hour in the paw edema test. A decrease in cellular infiltrate and down-modulation of NF-kB, besides the reduction of edema in the histopathology was observed. There was no evidence of kidney and liver toxicity and neurodepressive potential at the doses tested. Thus, baccharin has a promising anti-inflammatory effect possibly associated with antiedematogenic activity by inhibiting mediators such as prostaglandins, inhibiting the migration of polymorphonuclear cells, and modulating NF-kB expression. (AU)

• Processo FAPESP: 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático