Ectopic fat in muscle and poor glycemic control are negatively associated with trabecular bone score in type 2 diabetes

Autor(es)

Araujo, Iana Mizumukai de ; Salmon, Carlos Ernesto Garrido ; Paula, Francisco Jose Albuquerque de

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 79, p. 5-pg., 2024-07-10.

Resumo

Introduction: Type 2 Diabetes (T2D) is associated with fractures, despite preserved Bone Mineral Density (BMD). This study aimed to evaluate the relationship between BMD and trabecular bone score (TBS) with the reallocation of fat within muscle in individuals with eutrophy, obesity, and T2D. Methods: The subjects were divided into three groups: eutrophic controls paired by age and sex with the T2D group (n = 23), controls diagnosed with obesity paired by age, sex, and body mass index with the T2D group (n = 27), and the T2D group (n = 29). BMD and body fat percentage were determined using dual-energy X-Ray absorptiometry. TBS was determined using TBS iNsight software. Intra and extramyocellular lipids in the soleus were measured using proton magnetic resonance spectroscopy. Results: TBS was lower in the T2D group than in the other two groups. Glycated hemoglobin (A1c) was negatively associated with TBS. Body fat percentage was negatively associated with TBS and Total Hip (TH) BMD. TH BMD was positively associated with intramuscular lipids. A trend of negative association was observed between intramuscular lipids and TBS. Conclusion: This study showed for the first time that the reallocation of lipids within muscle has a negative association with TBS. Moreover, these results are consistent with previous studies showing a negative association between a parameter related to insulin resistance (intramuscular lipids) and TBS. (AU)

• Processo FAPESP: 21/03152-2 - Interação entre tecido adiposo, muscular e ósseo na anorexia nervosa
• Beneficiário: Iana Mizumukai de Araujo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/18071-5 - Homeostase hidroeletrolítica e energética: do metabolismo celular aos sistemas endócrinos em diferentes fases do desenvolvimento
• Beneficiário: Lucila Leico Kagohara Elias
• Modalidade de apoio: Auxílio à Pesquisa - Temático