| Texto completo | |
| Autor(es): |
Ferreira, Nathalia Lopes
;
Rocha, Igor Rafael Correia
;
Chacur, Marucia
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Lasers in Medical Science; v. 39, n. 1, p. 10-pg., 2024-08-22. |
| Resumo | |
Diabetic peripheral neuropathy (DPN) is a primary complication observed in diabetes that severely affects quality of life. Recent evidence suggests that photobiomodulation (PBM) is a promising therapy against painful conditions and nerve damage. However, the effects of PBM on DPN remains mostly unknown. In the present study, we investigated the efficacy of PBM therapy in modulating proinflammatory cytokine expression in both central and peripheral nervous systems of rats with Streptozotocin (STZ)-induced type 1 diabetes. Male Wistar rats were allocated into control (naive), diabetic (STZ), and treatment (STZ + PBM) groups. A single intraperitoneal (i.p.) injection of STZ (85 mg/kg) was administered for the induction of diabetes. Animals were subjected to 10 treatment sessions, every other day. The results herein presented indicate that PBM treatment diminishes Receptor for Advanced Glycation End-products (RAGE) and Nuclear Factor Kappa B (NF-kappa B) expression in peripheral nervous system and suppresses TNF-alpha expression in central nervous system tissues. Furthermore, PBM-therapy in diabetic rats also induces increased levels of the anti-inflammatory protein IL-10 in both peripheral and central nervous system. Collectively, our findings demonstrate compelling evidence that PBM-therapy modulates cytokine dynamics and influences RAGE/NF-kappa B axis in a STZ-induced model of type 1 diabetes. (AU) | |
| Processo FAPESP: | 17/05218-5 - Efeito da fotobioestimulação em diferentes neuropatias periférica em ratos. |
| Beneficiário: | Marucia Chacur |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/25554-0 - Estudo dos efeitos da fotobioestimulação sobre o metabolismo energético mitocondrial das células de Schwann no Diabetes Mellitus Tipo 1 |
| Beneficiário: | Igor Rafael Correia Rocha |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |