| Texto completo | |
| Autor(es): Mostrar menos - |
Noronha, Natalia Yumi
;
Noma, Isabella Harumi Yonehara
;
Fernandes Ferreira, Rafael
;
Rodrigues, Guilherme da Silva
;
Martins, Luzania dos Santos
;
Watanabe, Ligia Moriguchi
;
Pinhel, Marcela Augusta de Souza
;
Mello Schineider, Isabelle
;
Diani, Luisa Maria
;
Carlos, Daniela
;
Nonino, Carla Barbosa
Número total de Autores: 11
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| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN NUTRITION; v. 11, p. 9-pg., 2024-04-04. |
| Resumo | |
Introduction: There is an emerging body of evidence that vitamin C consumption can modulate microbiota abundance and can also impact DNA methylation in the host, and this could be a link between diet, microbiota, and immune response. The objective of this study was to evaluate common CpG sites associated with both vitamin C and microbiota phyla abundance. Methods: Six healthy women participated in this cohort study. They were divided into two groups, according to the amount of vitamin C they ingested. Ingestion was evaluated using the 24-h recall method. The Illumina 450 k BeadChip was used to evaluate DNA methylation. Singular value decomposition analyses were used to evaluate the principal components of this dataset. Associations were evaluated using the differentially methylated position function from the Champ package for R Studio. Results and discussion: The group with higher vitamin C (HVC) ingestion also had a higher relative abundance of Actinobacteria. There was a positive correlation between those variables (r = 0.84, p = 0.01). The HVC group also had higher granulocytes, and regarding DNA methylation, there were 207 CpG sites commonly related to vitamin C ingestion and the relative abundance of Actinobacteria. From these sites, there were 13 sites hypomethylated and 103 hypermethylated. The hypomethylated targets involved the respective processes: immune function, glucose homeostasis, and general cellular metabolism. The hypermethylated sites were also enriched in immune function-related processes, and interestingly, more immune responses against pathogens were detected. These findings contribute to understanding the interaction between nutrients, microbiota, DNA methylation, and the immune response. (AU) | |
| Processo FAPESP: | 14/16740-6 - Expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso |
| Beneficiário: | Natália Yumi Noronha |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |
| Processo FAPESP: | 18/24069-3 - Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua |
| Beneficiário: | Fernando Barbosa Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |