| Texto completo | |
| Autor(es): |
Takano, Ana Paula Cremasco
;
de Andre, Carmen Diva Saldiva
;
de Almeida, Raquel
;
Waked, Dunia
;
Veras, Mariana Matera
;
Saldiva, Paulo Hilario Nascimento
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Environmental Research; v. 248, p. 8-pg., 2024-02-04. |
| Resumo | |
Evidence suggests that myocardial interstitial fibrosis, resulting from cardiac remodeling, may possibly be influenced by mechanisms activated through the inhalation of airborne pollutants. However, limited studies have explored the relationship between lifetime exposure to carbon-based particles and cardiac fibrosis, specially using post -mortem samples. This study examined whether long -term exposure to air pollution (estimated by black carbon accumulated in the lungs) is associated with myocardial fibrosis in urban dwellers of megacity of Sao Paulo. Data collection included epidemiological and autopsy-based approaches. Information was obtained by interviewing the next of kin and through the pathologist's report. The individual index of exposure to carbonbased particles, which we designed as the fraction of black carbon (FBC), was estimated through quantification of particles on the macroscopic lung surface. Myocardium samples were collected for histopathological analysis to evaluate the fraction of cardiac fibrosis. The association between cardiac fibrosis and FBC, age, sex, smoking status and hypertension was assessed by means of multiple linear regression models. Our study demonstrated that the association of FBC with cardiac fibrosis is influenced by smoking status and hypertension. Among hypertensive individuals, the cardiac fibrosis fraction tended to increase with the increase of the FBC in both groups of smokers and non-smokers. In non-hypertensive individuals, the association between cardiac fibrosis fraction and FBC was observed primarily in smokers. Long -term exposure to tobacco smoke and environmental particles may contribute to the cardiac remodeling response in individuals with pre-existing hypertension. This highlights the importance of considering hypertension as an additional risk factor for the health effects of air pollution on the cardiovascular system. Moreover, the study endorses the role of autopsy to investigate the effects of urban environment and personal habits in determining human disease. (AU) | |
| Processo FAPESP: | 19/06435-5 - Mecanismos celulares e moleculares envolvidos no envelhecimento cardíaco: efeitos da supressão específica de NF-kB em cardiomiócitos |
| Beneficiário: | Ana Paula Cremasco Takano |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/23129-7 - Impacto da exposição crônica à poluição atmosférica no envelhecimento do miocárdio |
| Beneficiário: | Ana Paula Cremasco Takano |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/21728-2 - Uso de modernas técnicas de autópsia na investigação de doenças humanas (MODAU) |
| Beneficiário: | Paulo Hilário Nascimento Saldiva |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |