Silk fibroin-derived electrospun materials for biomedical applications: A review

Autor(es)

Santos, Francisco Vieira dos ; Siqueira, Renato Luiz ; Ramos, Lucas de Morais ; Yoshioka, Sergio Akinobu ; Branciforti, Marcia Cristina ; Correa, Daniel Souza

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 254, p. 34-pg., 2023-11-08.

Resumo

Electrospinning is a versatile technique for fabricating polymeric fibers with diameters ranging from micro-to nanoscale, exhibiting multiple morphologies and arrangements. By combining silk fibroin (SF) with synthetic and/or natural polymers, electrospun materials with outstanding biological, chemical, electrical, physical, mechanical, and optical properties can be achieved, fulfilling the evolving biomedical demands. This review highlights the remarkable versatility of SF-derived electrospun materials, specifically focusing on their application in tissue regeneration (including cartilage, cornea, nerves, blood vessels, bones, and skin), disease treatment (such as cancer and diabetes), and the development of controlled drug delivery systems. Additionally, we explore the potential future trends in utilizing these nanofibrous materials for creating intelligent bio-materials, incorporating biosensors and wearable sensors for monitoring human health, and also discuss the bottlenecks for its widespread use. This comprehensive overview illuminates the significant impact and exciting prospects of SF-derived electrospun materials in advancing biomedical research and applications. (AU)

• Processo FAPESP: 18/22214-6 - Rumo à convergência de tecnologias: de sensores e biossensores à visualização de informação e aprendizado de máquina para análise de dados em diagnóstico clínico
• Beneficiário: Osvaldo Novais de Oliveira Junior
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 22/05316-5 - Desenvolvimento de biomateriais poliméricos funcionais visando à regeneração e cicatrização tecidual
• Beneficiário: Francisco Vieira dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/26194-7 - Fabricação e caracterização de nanofibras de alginato/fibroína de seda incorporadas com óleo de pequi aplicadas no tratamento de feridas cutâneas
• Beneficiário: Francisco Vieira dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado