| Texto completo | |
| Autor(es): |
Portas, Carolina Morales
;
Garcia, Geovana Stefani
;
Gaspar, Renato Simoes
;
Casagrande, Annelise da Silva
;
Tanaka, Leonardo Yuji
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ADVANCES IN REDOX RESEARCH; v. 6, p. 11-pg., 2022-12-01. |
| Resumo | |
Vasomotricity, defined by measurements of contraction or relaxation, is important to support correct blood supply and needs to be finely regulated during hemodynamic changes. Disruptions in either contraction or relaxation, mainly endothelium-mediated, are closely related to cardiovascular diseases and are found during early events of vascular structural alterations, including vessel remodeling. Both acute vasomotor changes and chronic vascular remodeling are regulated by redox processes, such as the production of nitric oxide (NO), which is the major vasoactive endothelium-derived paracrine molecule. However, it is still unclear if vasomotricity can be regulated by direct redox reactions or thiol posttranslational modifications induced by secondary mediators. Here, we have reviewed the literature concerning the control of vascular function based on redox processes and merged evidence with mechanisms supporting structural alterations. Such knowledge is important to summarize the resulting vascular effects that occur upon inhibition of specific redox regulators. This may provide a landscape to better understand the complex redox regulation of vasomotricity and determine a hierarchical map of events involving NO biology, calcium transient regulation, actin cytoskeleton and extracellular matrix organization. In addition, we have proposed that the thiol oxidoreductase protein disulfide isomerase A1 (PDI) has the potential to act as a central hub connecting these processes with local oxidant generation, which may globally impact vascular function in physiologic and pathologic processes. Altogether, the understanding of these redox processes may lead to potential therapeutic redox targets able to prevent or treat functional or structural vascular alterations. (AU) | |
| Processo FAPESP: | 20/04280-1 - Mecanismos subcelulares envolvidos na convergência entre homeostase mecânica e redox na regulação vascular |
| Beneficiário: | Leonardo Yuji Tanaka |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |
| Processo FAPESP: | 20/15944-8 - Investigação da proteína disulfeto isomerase peri/epicelular como um novo regulador da interação plaqueta-endotélio em normoglicemia e Diabetes |
| Beneficiário: | Renato Simões Gaspar |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/07230-5 - Mecanismos subcelulares envolvidos na convergência entre homeostase mecânica e redox na regulação vascular |
| Beneficiário: | Leonardo Yuji Tanaka |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/18448-4 - Estudo da regulação via óxido nítrico na resposta ao estiramento cíclico fisiológico e patológico em células endoteliais |
| Beneficiário: | Geovana Stefani Garcia |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |