| Texto completo | |
| Autor(es): Mostrar menos - |
Prado, Vilma M. J.
;
de Jesus, Raphael A.
;
Oliveira, Julio M. A.
;
Pereira, Camila S. A.
;
Blank, Arie F.
;
Pereira-Filho, Edenir R.
;
Cass, Quezia B.
;
de Lima, Juliana M.
;
Ferreira, Antonio G.
;
Nogueira, Paulo C. L.
;
Moraes, Valeria R. S.
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 32, n. 2, p. 10-pg., 2021-02-01. |
| Resumo | |
Croton grewioides Baill. popularly known as "canelinha" or "canelinha-de-cheiro" has been used for the treatment of influenza, antitussive, febrifuge and headache; however, the study of its phytochemical composition is limited. The aim of this study was to investigate the effect of the extraction method and seasonality through leaf extracts of four accessions of Croton grewioides by fingerprint chromatograms aided by principal component analysis to analyze the differences and similarities among the samples. We aimed also to provide chemical characterization of isolated secondary metabolites using semi-preparative liquid chromatography. The results showed that only the chemical profile of the methanolic extracts of accessions 101 and 113 were influenced by the seasonality. For the first time, four flavonoids were isolated through semi-preparative chromatography in this species, characterized as quercetin 3-O-beta-D-galactopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside-(1 -> 6)-alpha-L-rhamnopyranoside (1), quercetin 3-O-beta-D-galactopyranosyl-(1 -> 2)-alpha-apiopyranoside-(1 -> 6)-alpha-L-rhamnopyranoside (2), quercetin 3-O-glucopyranoside (3) and 3-O-methyl-quercetin (4), the flavonoid (2) has been recognized as a new triglycosylated derivative. (AU) | |
| Processo FAPESP: | 13/01710-1 - Ligantes enzimáticos: novos modelos de triagem |
| Beneficiário: | Quezia Bezerra Cass |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/50299-5 - EMU - espectrômetro de massas modelo Amazon speed com fonte ESI e duplo funil de íons, analisador tipo íon TRAP |
| Beneficiário: | Quezia Bezerra Cass |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 14/11640-3 - Métodos LC-MS/2D para triagem de ligantes para a avaliação de atividade inibitória de enzimas e identificação dos compostos ativos em extratos brutos |
| Beneficiário: | Cláudia Seidl |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |