| Texto completo | |
| Autor(es): |
Candido, Ana Carolina Bolela Bovo
;
Pagotti, Mariana Cintra
;
dos Santos, Daiane Albino
;
Paula, Lucas Antonio de Lima
;
Veneziani, Rodrigo Cassio Sola
;
Bastos, Jairo Kenupp
;
Ambrosio, Sergio Ricardo
;
Magalhaes, Lizandra Guidi
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACEUTICALS; v. 17, n. 9, p. 11-pg., 2024-09-01. |
| Resumo | |
Background/Objectives: Leishmaniasis, a neglected disease caused by Leishmania spp. including L. amazonensis, urgently requires new treatments. Polyalthic acid (PA), a natural diterpene from Copaifera spp., has previously demonstrated significant antiparasitic potential. This study evaluated the leishmanicidal effects of polyalthic acid (PA), alone and with amphotericin B (AmpB), on L. amazonensis promastigote and amastigote forms. Results: PA showed significant activity against promastigotes, with 50% effective concentration (EC50) values of 2.01 mu M at 24 h and an EC50 of 3.22 mu M against amastigotes after 48 h. The PA and AmpB combination exhibited a synergistic effect on both forms without inducing cytotoxicity or hemolysis. Morphological changes in promastigotes, including vacuole formation and cell rounding, were more pronounced with the combination. Conclusions: These findings suggest that PA and AmpB together could form a promising new treatment strategy against Leishmania infections, offering enhanced efficacy without added toxicity. (AU) | |
| Processo FAPESP: | 11/13630-7 - Validação química e farmacológica de extratos e princípios ativos de espécies de Copaifera |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 16/08135-0 - Estudo da combinação dos diterpenos ácido caurenóico e ácido poliáltico com anfotericina B nas formas promastigotas e amastigotas de Leishmania amazonensis |
| Beneficiário: | Ana Carolina Bolela Bovo Candido |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |