Investigating the Antibacterial and Antitumoral Activities of New Copper(II) Complexes with Trifluoromethyluracil Isomers

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Pereira, Gabriele de Menezes ; Nunes, Julia Helena Bormio ; Frajacomo, Silmara Cristina Lazarini ; Lustri, Wilton Rogerio ; Bergamini, Fernando Rodrigues Goulart ; Moreira, Joselia Cristina de Oliveira ; Pontes, Robson ; Ruiz, Ana Lucia T. G. ; de Carvalho, Joao Ernesto ; Barros, Wdeson Pereira ; Corbi, Pedro Paulo

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 10, n. 6, p. 8-pg., 2025-02-01.

Resumo

New copper(II) complexes, derived from the isomers 5-(trifluoromethyl)uracil (L1) and 6-(trifluoromethyl)uracil (L2) with 2,2 '-bipyridine (Bpy), [Cu(H2O)(L1)2Bpy] and [Cu(H2O)(L2)2Bpy], were synthesized, characterized, and evaluated for their antibacterial and antitumoral properties. Chemical analyses suggest the molecular formula CuC20H12F6N6O4<middle dot>H2O for both complexes. Infrared spectroscopic analyses indicate that trifluoromethyluracil isomers coordinate to copper(II) by the oxygen atoms. Structural confirmation of the [Cu(H2O)(L2)2Bpy] complex was obtained by single crystal X-ray diffraction, where two L2 molecules coordinate to the copper(II) ion by both oxygen atoms from carbonyl groups. The complexes demonstrated antibacterial activity against Gram-positive Staphylococcus aureus and Bacillus cereus, and Gram-negative Pseudomonas aeruginosa and Escherichia coli strains. The [Cu(H2O)(L1)2Bpy] complex exhibited the most promising results against P. aeruginosa, with a minimum inhibitory concentration (MIC) value of 0.478 mmol L-1. The [Cu(H2O)(L1)2Bpy] complex demonstrated antiproliferative effects on U251 and MCF-7 cells, with GI50 values (concentration that inhibits 50% of cell growth) of 2.18 +/- 1.17 and 16.00 +/- 10.07 mu mol<middle dot>L-1, whereas the [Cu(H2O)(L2)2Bpy] complex inhibited the growth of FaDu and U251 cells (GI50 values 4.70 +/- 2.69 mu mol<middle dot>L-1 and 9.06 +/- 3.86 mu mol<middle dot>L-1, respectively). Neither the precursors nor the copper(II) complexes affected the structure of CT-DNA at the evaluated concentrations, suggesting that DNA is not the main cellular target of the complexes. (AU)

• Processo FAPESP: 21/10265-8 - Centro de Inovação Teranóstica em Câncer (CancerThera)
• Beneficiário: Carmino Antonio de Souza
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs