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Assessing azithromycin's ecological toll: Unveiling multifaceted impacts on Poecilia reticulata THROUGH biomarker analysis

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Autor(es):
Marinsek, Gabriela Pustiglione ; Tagliamento, Manuela Agullo ; Oliveira, Isabelly Cristina Correia dos Santos ; Capaldo, Anna ; Gusso-Choueri, Paloma Kachel ; Feitosa, Ana Carolina Cruz ; Abessa, Denis Moledo de Souza ; Oliveira, Marcos Antonio ; Mari, Renata de Britto
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 113, p. 9-pg., 2024-12-21.
Resumo

This study investigates the impact of environmentally relevant concentrations of azithromycin on Poecilia reticulata, through biomarkers at different levels. To this end, the somatic indexes of P. reticulata were evaluated, and liver and gill samples were collected and analyzed for biochemical and histopathological alterations. Azithromycin caused significant effects in P. reticulata, such as increased hepatosomatic index, altered redox responses, particularly in gills, indicating oxidative stress, and notable tissue damage in the liver and gills in a dosedependent response manner. Principal Component Analysis highlighted differences between control and exposed groups, demonstrating the azithromycin's influence on organismal homeostasis. This research underscores the importance of understanding azithromycin action in nontarget organisms of aquatic environments. (AU)

Processo FAPESP: 23/06413-7 - SETAC Latin America 15th Biennial Meeting
Beneficiário:Renata de Britto Mari
Modalidade de apoio: Auxílio à Pesquisa - Reunião - Exterior
Processo FAPESP: 14/07793-9 - Avaliação da ação antrópica sobre aspectos morfofuncionais de baiacus Sphoeroides testudineus (Tetradontiformes: Tetradontidae) no complexo estuarino de Santos e Peruíbe, São Paulo
Beneficiário:Renata de Britto Mari
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 20/03004-0 - Avaliação da bioacumulação e toxicidade de nanomateriais anti-incrustantes inovadores em invertebrados marinhos neotropicais e subtropicais
Beneficiário:Denis Moledo de Souza Abessa
Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular