Cytotoxic potential of polymeric nanoparticles loaded with Brazilian red propolis in breast cancer

Autor(es)

Justino, Isabela A. ; Ferreira, Iasmin R. S. ; Botteon, Caroline A. ; Tucci, Luiz Fernando F. ; Amaral, Robson ; Aldana-Mejia, Jennyfer A. ; Gonsalves, Yasmin G. ; Bastos, Jairo K. ; Marzocchi-Machado, Cleni M. ; Marcato, Priscyla D.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 105, p. 12-pg., 2025-03-01.

Resumo

Breast cancer (BC) remains a significant public health concern globally, with increasing incidence and mortality rates among women. Nanoparticle-based drug delivery systems offer promising avenues for improving cancer therapy efficacy and reducing adverse effects. In this study, Transmission Electron Microscopy (TEM) and Fourier Transform Infrared Spectroscopy (FTIR) were employed to characterize polymeric nanoparticles encapsulating Brazilian red propolis extract (BRPE). TEM confirmed the spherical morphology and expected size of the nanoparticles, while FTIR indicated successful encapsulation of the extract and its interaction with the polymeric matrix. Cytotoxicity tests revealed that nanoparticle-encapsulated BRPE (NCBRPE) exhibited reduced toxicity to normal breast cells (MCF-10) but increased toxicity to breast cancer cells (MCF-7) compared to free BRPE, suggesting targeted therapeutic potential. Notably, NCBRPE demonstrated enhanced efficacy in acidic tumor microenvironments, further supporting its targeted therapeutic potential. The consistent results across 2D and 3D models highlight the reliable antitumor activity of NCBRPE, positioning it as a promising candidate for breast cancer therapy. (AU)

• Processo FAPESP: 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/13465-5 - Desenvolvimento de nanopartículas poliméricas contendo própolis vermelha brasileira e avaliação antitumoral in vitro e in vivo em cânceres urológicos
• Beneficiário: Priscyla Daniely Marcato Gaspari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/01655-7 - Resistoma, plasmidoma e viruloma de Enterobacterales isoladas do meio ambiente carreando genes mcr-like
• Beneficiário: Eliana Guedes Stehling
• Modalidade de apoio: Auxílio à Pesquisa - Regular