Assessment of antimicrobial effect of Biosilicate (R) against anaerobic, microaerophilic and facultative anaerobic microorganisms

Autor(es)

Gomes Martins, Carlos Henrique ^[1] ; Carvalho, Tatiane Cruz ^[1] ; Mendes Souza, Maria Gorete ^[1] ; Ravagnani, Christian ^[2] ; Peitl, Oscar ^[2] ; Zanotto, Edgar Dutra ^[2] ; Panzeri, Heitor ^[3] ; Casemiro, Luciana Assirati ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Lab Res Appl Microbiol, BR-14404600 Franca, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Mat Engn, Vitreous Mat Lab, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Sao Paulo, Dept Dent Mat & Prosthodont, Fac Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 22, n. 6, p. 1439-1446, JUN 2011.
• Citações Web of Science: 22

Resumo

This study assessed the antimicrobial activity of a new bioactive glass-ceramic (Biosilicate (R)) against anaerobic, microaerophilic, and facultative anaerobic microorganisms. Evaluation of the antimicrobial activity was carried out by three methods, namely agar diffusion, direct contact, and minimal inhibitory concentration (MIC). For the agar diffusion technique, bio glass-ceramic activity was observed against various microorganisms, with inhibition haloes ranging from 9.0 +/- 1.0 to 22.3 +/- 2.1 mm. For the direct contact technique, Biosilicate (R) displayed activity against all the microorganisms, except for S. aureus. In the first 10 min of contact between the microorganisms and Biosilicate (R), there was a drastic reduction in the number of viable cells. Confirming the latter results, MIC showed that the Biosilicate (R) inhibited the growth of microorganisms, with variations between <= 2.5 and 20 mg/ml. The lowest MIC values (7.5 to <= 2.5 mg/ml) were obtained for oral microorganisms. In conclusion, Biosilicate (R) exhibits a wide spectrum of antimicrobial properties, including anaerobic bacteria. (AU)

• Processo FAPESP: 05/01130-9 - Avaliacao da atividade antimicrobiana in vitro de um novo biovidro frente a microrganismos da cavidade bucal.
• Beneficiário: Carlos Henrique Gomes Martins
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/08179-9 - Processos cinéticos em vidros e vitrocerâmicas
• Beneficiário: Edgar Dutra Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Temático