Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mothers Immunized With Pneumococcal Polysaccharide Vaccine During Gestation

Autor(es)

Almeida, Volia de Carvalho ^{[1, 2]} ; Negrini, Bento V. M. ^{[1, 2]} ; Cervi, Maria C. ^[3] ; Isaac, Marcia de L. ^[3] ; Mussi-Pinhata, Marisa M. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Med Hlth, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Ctr Biol Sci, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC INFECTIOUS DISEASE JOURNAL; v. 30, n. 6, p. 466-470, JUN 2011.
• Citações Web of Science: 11

Resumo

Background: We have previously shown that 23-valent pneumococcal polysaccharide vaccine (PPV) is immunogenic in human immunodeficiency virus (HIV)-infected mothers and provides vaccine-induced antibodies to the infant. We compared the nasopharyngeal pneumococcal colonization (NPC) rates in <6-month-old infants born to HIV-infected mothers, according to immunization with PPV during pregnancy. Methods: NPC was evaluated in 45 term infants born to vaccinated women (PPV+) and in 60 infants in a control group (PPV-), at 2 months (+/- 30 days), 4 months (+/- 30 days), and 6 months (+/- 30 days) of age. Results: A total of 82 infants completed the study (at least 2 of 3 evaluations), 35 (77%) in the PPV+ and 47 (78.3%) in the PPV- groups, respectively. Infant gender, HIV infection status, number of adults, children, and smokers in the household, day-care attendance, occurrence of respiratory signs, and cotrimoxazole use were similar in both groups. NPC rates increased equally with age in both groups (2 months = 26.7% vs. 25.6%; 4 months = 34.5% vs. 38.6%; 6 months = 38.7% vs. 56.3%, in PPV+ and PPV-, respectively). After controlling for potential confounders, we found no association between maternal vaccination and infant pneumococcal carriage (adjusted odds ratio = 0.70; 95% confidence interval: 0.23, 2.21) Conclusions: Vaccination of HIV-infected mothers with PPV did not protect infants younger than 6 months of age from nasopharyngeal pneumococcal carriage. (AU)

• Processo FAPESP: 02/01294-3 - Imunizacao com a vacina pneumococica durante a gestacao em mulheres infecctadas pelo virus da imunodeficiencia humana (hiv): resposta vacinal materna e transmissao placentaria de anticorpos especificos.
• Beneficiário: Marisa Marcia Mussi
• Modalidade de apoio: Auxílio à Pesquisa - Regular