Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mothers Immunized With Pneumococcal Polysaccharide Vaccine During Gestation

Texto completo
Autor(es):
Almeida, Volia de Carvalho [1, 2] ; Negrini, Bento V. M. [1, 2] ; Cervi, Maria C. [3] ; Isaac, Marcia de L. [3] ; Mussi-Pinhata, Marisa M. [3]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Med Hlth, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Ctr Biol Sci, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: PEDIATRIC INFECTIOUS DISEASE JOURNAL; v. 30, n. 6, p. 466-470, JUN 2011.
Citações Web of Science: 12
Resumo

Background: We have previously shown that 23-valent pneumococcal polysaccharide vaccine (PPV) is immunogenic in human immunodeficiency virus (HIV)-infected mothers and provides vaccine-induced antibodies to the infant. We compared the nasopharyngeal pneumococcal colonization (NPC) rates in <6-month-old infants born to HIV-infected mothers, according to immunization with PPV during pregnancy. Methods: NPC was evaluated in 45 term infants born to vaccinated women (PPV+) and in 60 infants in a control group (PPV-), at 2 months (+/- 30 days), 4 months (+/- 30 days), and 6 months (+/- 30 days) of age. Results: A total of 82 infants completed the study (at least 2 of 3 evaluations), 35 (77%) in the PPV+ and 47 (78.3%) in the PPV- groups, respectively. Infant gender, HIV infection status, number of adults, children, and smokers in the household, day-care attendance, occurrence of respiratory signs, and cotrimoxazole use were similar in both groups. NPC rates increased equally with age in both groups (2 months = 26.7% vs. 25.6%; 4 months = 34.5% vs. 38.6%; 6 months = 38.7% vs. 56.3%, in PPV+ and PPV-, respectively). After controlling for potential confounders, we found no association between maternal vaccination and infant pneumococcal carriage (adjusted odds ratio = 0.70; 95% confidence interval: 0.23, 2.21) Conclusions: Vaccination of HIV-infected mothers with PPV did not protect infants younger than 6 months of age from nasopharyngeal pneumococcal carriage. (AU)

Processo FAPESP: 02/01294-3 - Imunização com a vacina pneumocócica durante a gestação em mulheres infecctadas pelo vírus da imunodeficiência humana (HIV): resposta vacinal materna e transmissão placentária de anticorpos específicos
Beneficiário:Marisa Marcia Mussi
Linha de fomento: Auxílio à Pesquisa - Regular