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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mothers Immunized With Pneumococcal Polysaccharide Vaccine During Gestation

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Author(s):
Almeida, Volia de Carvalho [1, 2] ; Negrini, Bento V. M. [1, 2] ; Cervi, Maria C. [3] ; Isaac, Marcia de L. [3] ; Mussi-Pinhata, Marisa M. [3]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Med Hlth, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Ctr Biol Sci, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PEDIATRIC INFECTIOUS DISEASE JOURNAL; v. 30, n. 6, p. 466-470, JUN 2011.
Web of Science Citations: 11
Abstract

Background: We have previously shown that 23-valent pneumococcal polysaccharide vaccine (PPV) is immunogenic in human immunodeficiency virus (HIV)-infected mothers and provides vaccine-induced antibodies to the infant. We compared the nasopharyngeal pneumococcal colonization (NPC) rates in <6-month-old infants born to HIV-infected mothers, according to immunization with PPV during pregnancy. Methods: NPC was evaluated in 45 term infants born to vaccinated women (PPV+) and in 60 infants in a control group (PPV-), at 2 months (+/- 30 days), 4 months (+/- 30 days), and 6 months (+/- 30 days) of age. Results: A total of 82 infants completed the study (at least 2 of 3 evaluations), 35 (77%) in the PPV+ and 47 (78.3%) in the PPV- groups, respectively. Infant gender, HIV infection status, number of adults, children, and smokers in the household, day-care attendance, occurrence of respiratory signs, and cotrimoxazole use were similar in both groups. NPC rates increased equally with age in both groups (2 months = 26.7% vs. 25.6%; 4 months = 34.5% vs. 38.6%; 6 months = 38.7% vs. 56.3%, in PPV+ and PPV-, respectively). After controlling for potential confounders, we found no association between maternal vaccination and infant pneumococcal carriage (adjusted odds ratio = 0.70; 95% confidence interval: 0.23, 2.21) Conclusions: Vaccination of HIV-infected mothers with PPV did not protect infants younger than 6 months of age from nasopharyngeal pneumococcal carriage. (AU)