| Texto completo | |
| Autor(es): |
Trajano, Isis P.
;
Costa, Luis Henrique Angenendt
;
Passaglia, Patricia
;
Santos, Wanderson S.
;
dos Santos, Jonathas Rodrigo
;
Alberici, Luciane Carla
;
Branco, Luiz G. S.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CYTOKINE; v. 189, p. 7-pg., 2025-03-08. |
| Resumo | |
An abnormally elevated mortality rate is evident in cases of sepsis. To study specific mechanisms of sepsis experimentally, lipopolysaccharide (LPS) systemically administered has been used as a model, in which an exaggerated immune response, neurochemistry settings, and fever following hypothermia take place. Notably, systemic inflammation (SI) can modulate the central serotonergic pathways and being influenced by it. This influence extends to the hypothalamus, which holds a hierarchical significance in the control of body temperature (Tb). This study investigates the potential impact of orally administered fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI) given orally for 7 days before on LPS-induced SI (1.5 mg/kg, i.v.) in rats. The assessment involved monitoring Tb, heat loss index (HLI), along non-shivering thermogenesis assessed by oxygen consumption. Cytokine levels in the spleen and blood, along with nitric oxide (NO), and prostaglandins (PGs) E2 and D2, levels were also measured. The findings reveal increased plasma NO, cytokines in plasma and spleen, and hypothalamus PGE2 levels during SI. Interestingly, FLX mitigated LPS-induced hypothermia, accompanied by a reduction in plasma and splenic NO, interleukins (IL) 6, and 10. Additionally, the results align with the hypothesis that hypothermia, blunted by FLX, develops in fact in a regulated form, as an adaptive strategy. (AU) | |
| Processo FAPESP: | 22/01783-8 - Efeitos do pré-tratamento com fluoxetina sobre a hipotermia induzida por endotoxemia |
| Beneficiário: | Isis Paiva Trajano |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 22/12290-2 - Efeito do Citral na Doença Periodontal em ratos |
| Beneficiário: | Luiz Guilherme de Siqueira Branco |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/17681-9 - Alterações fisiopatológicas durante a inflamação sistêmica |
| Beneficiário: | Luiz Guilherme de Siqueira Branco |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |