A Concise Account on Organocatalyzed Asymmetric Synthesis of Epoxide and Aziridine Derivatives from α,β-Unsaturated Carbonyl Compounds

Autor(es)

Martinez, Alice K. de A. ; Mourao, Penina S. ; Correa, Arlene G.

• Tipo de documento: Artigo Científico
• Fonte: Synlett; v. N/A, p. 9-pg., 2025-03-12.

Resumo

Epoxides and aziridines are important pharmacologically active compounds that are found in many drugs. These three-membered rings are also employed in the synthesis of a wide range of other heterocycles. In this account, we highlight the contributions of our research group to the organocatalyzed asymmetric synthesis of epoxides and aziridines from a,(3-unsaturated carbonyl compounds, followed by multicomponent reactions that afford novel peptidomimetics. Additionally, these scaffolds have been employed in the synthesis of lac- tones, lactams, and hydantoins, showcasing their versatility in drug development and synthetic chemistry. (AU)

• Processo FAPESP: 24/05518-2 - Síntese de N-heterociclos de cinco membros empregando métodos verdes
• Beneficiário: Alice Karoline de Almeida Martinez
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 21/12394-0 - Métodos sintéticos sustentáveis empregando catálise, solventes verdes, reagentes seguros e materiais de partida renováveis
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Temático