Busca avançada
Ano de início
Entree
Conteúdo relacionado
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation

Texto completo
Autor(es):
Danilovic, A. [1] ; Lucon, A. M. [1] ; Srougi, M. [1] ; Shimizu, M. H. M. [2] ; Ianhez, L. E. [1] ; Nahas, W. C. [1] ; Seguro, A. C. [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo Gen Hosp, Div Urol, Dept Surg, Sao Paulo - Brazil
[2] Univ Sao Paulo Gen Hosp, Dept Internal Med, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Transplantation Proceedings; v. 43, n. 5, p. 1443-1449, JUN 2011.
Citações Web of Science: 25
Resumo

We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment (n = 38) or control (n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days (P = .026) and at 1 year after transplantation (P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group (P = .017) and these recipients required fewer days of dialysis (P = .012). Oxidative stress was significantly attenuated with NAC (P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress. (AU)

Processo FAPESP: 06/52046-0 - Estresse oxidativo e funcao renal pos-operatoria em transplante renal de doador de cadaver.
Beneficiário:Antonio Marmo Lucon
Modalidade de apoio: Auxílio à Pesquisa - Regular