Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation

Author(s)

Danilovic, A. ^[1] ; Lucon, A. M. ^[1] ; Srougi, M. ^[1] ; Shimizu, M. H. M. ^[2] ; Ianhez, L. E. ^[1] ; Nahas, W. C. ^[1] ; Seguro, A. C. ^[2]

Affiliation

^[1] Univ Sao Paulo Gen Hosp, Div Urol, Dept Surg, Sao Paulo - Brazil

^[2] Univ Sao Paulo Gen Hosp, Dept Internal Med, Sao Paulo - Brazil

• Document type: Journal article
• Source: Transplantation Proceedings; v. 43, n. 5, p. 1443-1449, JUN 2011.
• Web of Science Citations: 25

Abstract

We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment (n = 38) or control (n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days (P = .026) and at 1 year after transplantation (P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group (P = .017) and these recipients required fewer days of dialysis (P = .012). Oxidative stress was significantly attenuated with NAC (P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress. (AU)