| Texto completo | |
| Autor(es): |
de Dourado, Janaina Araujo E.
;
Lopes, Samuel Q.
;
Accioly Jr, Marcos
;
Raminelli, Cristiano
;
Jimenez, David E. Q.
;
Porto, Andre L. M.
;
Ferreira, Irlon M.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | WASTE AND BIOMASS VALORIZATION; v. N/A, p. 9-pg., 2025-04-07. |
| Resumo | |
The rich biological heritage of Brazil, especially that of the Amazon, stands out as a strategic environment for exploitation of new microorganisms. In this study, the endophytic fungus Penicillium paxilli, isolated from Bertholletia excelsa nuts, was applied to biotransformation of progesterone. Whole cells of this fungus were immobilized on silk fibroin (from the cocoon of Bombyx mori) and on chitin (from the shell of the Amazon shrimp). In all cases, testololactone was identified as the major product of the reaction: 92% in free cells, 75% in cells immobilized on silk fibroin and 54% in cells immobilized on chitin at 5 days. After one month of biocatalyst storage, the system utilizing cells immobilized on silk fibroin demonstrated superior performance in maintaining the biocatalytic activity of the fungus P. paxilli for the biotransformation of progesterone into testololactone, compared to both free-cell systems and cells immobilized on chitin. (AU) | |
| Processo FAPESP: | 18/15904-6 - Caracterização de inibidores de cisteíno proteases com atividade antineoplásica por meio de ensaios in silico, celulares e análise química |
| Beneficiário: | Andrei Leitão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |