| Texto completo | |
| Autor(es): Mostrar menos - |
Rodrigues, Marcio L.
;
Janbon, Guilhem
;
O'Connell, Richard J.
;
Chu, Thi-Thu-Huyen
;
May, Robin C.
;
Jin, Hailing
;
Reis, Flavia C. G.
;
Alves, Lysangela R.
;
Puccia, Rosana
;
Fill, Taicia P.
;
Rizzo, Juliana
;
Zamith-Miranda, Daniel
;
Miranda, Kildare
;
Goncalves, Teresa
;
Ene, Iuliana V.
;
Kabani, Mehdi
;
Anderson, Marilyn
;
Gow, Neil A. R.
;
Andes, David R.
;
Casadevall, Arturo
;
Nosanchuk, Joshua D.
;
Nimrichter, Leonardo
Número total de Autores: 22
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURE MICROBIOLOGY; v. N/A, p. 11-pg., 2025-03-27. |
| Resumo | |
Since their discovery in 2007, there has been growing awareness of the importance of fungal extracellular vesicles (EVs) for fungal physiology, host-pathogen interactions and virulence. Fungal EVs are nanostructures comprising bilayered membranes and molecules of various types that participate in several pathophysiological processes in fungal biology, including secretion, cellular communication, immunopathogenesis and drug resistance. However, many questions remain regarding the classification of EVs, their cellular origin, passage across the cell wall, experimental models for functional and compositional analyses, production in vitro and in vivo and biomarkers for EVs. Here, we discuss gaps in the literature of fungal EVs and identify key questions for the field. We present the history of fungal EV discovery, discuss five major unanswered questions in fungal EV biology and provide future perspectives for fungal EV research. We primarily focus our discussion on human fungal pathogens, but also extend it to include knowledge of other fungi, such as plant pathogens. With this Perspective we hope to stimulate new approaches and expand studies to understand the biology of fungal EVs. (AU) | |
| Processo FAPESP: | 22/11123-5 - Novos aspectos sobre o papel de componentes de vesículas extracelulares de fungos patogênicos humanos na transmissão de estímulos e no curso da infecção |
| Beneficiário: | Rosana Puccia |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/02992-0 - Decifrando o papel de metabólitos secundários na interação química entre fitopatógenos e o hospedeiro citros |
| Beneficiário: | Taicia Pacheco Fill |
| Modalidade de apoio: | Auxílio à Pesquisa - Projeto Inicial |