Cellular death but not genetic damage in oral mucosa cells after exposure to digital lateral radiography

Autor(es)

Ribeiro, Daniel A. ^{[1, 2]} ; Sannomiya, Eduardo K. ^{[3, 4]} ; Pozzi, Renan ^[2] ; Miranda, Sandra R. ^[1] ; Angelieri, Fernanda ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Patol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, BR-11060001 Sao Paulo - Brazil

^[3] Sao Paulo Methodist Univ, Dept Orthodont, UMESP, Sao Paulo - Brazil

^[4] Sao Paulo Methodist Univ, Dept Dentomaxillofacial Radiol, UMESP, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 15, n. 3, p. 357-360, JUN 2011.
• Citações Web of Science: 9

Resumo

The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from individuals following digital lateral radiography. A total of 30 healthy patients (15 men and 15 women) indicated to the orthodontic therapy were submitted to digital lateral X-ray. Exfoliated oral mucosa cells were collected immediately before the X-ray exposure and after 10 days. The results pointed out no significant statistically differences (p > 0.05) of micronucleated oral mucosa cells. On the other hand, X-ray was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis, and karyolysis. In summary, these data indicate that exposure to digital lateral radiography may not be a factor that induced chromosomal damage, but it is able to promote cytotoxicity. (AU)

• Processo FAPESP: 07/01228-4 - Carcinogênese bucal quimicamente induzida pela 4-nitroquinolina 1-óxido em ratos: possíveis biomarcadores envolvidos em sua patogênese
• Beneficiário: Daniel Araki Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores