| Texto completo | |
| Autor(es): |
Aldana-Mejia, Jennyfer Andrea
;
Rezende Granzoto, Marina
;
de Melo, Eveline Maria
;
Ribeiro, Victor Pena
;
Ross, Samir A.
;
Marcato, Priscyla D.
;
Furtado, Ricardo Andrade
;
Bastos, Jairo Kenupp
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRY & BIODIVERSITY; v. N/A, p. 8-pg., 2025-03-01. |
| Resumo | |
The Brazilian Caatinga green propolis (GP) is known for its significant biological activities; however, its incorporation into pharmaceutical formulations is hindered by its resinous nature and low solubility. This study investigates the analgesic and anti-inflammatory effects of both free GP and nanoencapsulated GP (GPN). The optimized oil/water nanoformulation maintained stability over a period of 28 days, exhibiting minimal alterations in particle size (approximately 200 nm) and polydispersity index (PdI). GPN demonstrated notable inhibition of nociception at a concentration of 27 mg/kg in mice during the formalin test. In the thermal stimulus test, GP exhibited significant analgesic effects at 9 and 60 mg/kg in phase I, whereas GPN achieved this effect at 9 mg/kg. In phase II, GP at 90 mg/kg showed analgesic effects in response to thermal stimuli. GPN also reduced edema from the third hour onward at 9 mg/kg, matching the effects of higher GP concentrations (90 mg/kg). These findings underscore the enhanced efficacy of GPN. Although this preliminary formulation requires further optimization, it demonstrated promising biological activity in the evaluated assays. (AU) | |
| Processo FAPESP: | 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |