| Texto completo | |
| Autor(es): |
Martins, Yandara A.
;
Cardinali, Camila A. E. F.
;
Torrao, Andrea S.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROBIOLOGY OF AGING; v. 150, p. 25-pg., 2025-03-04. |
| Resumo | |
Astrocytes are neuromodulator cells. Their complex and dynamic morphology regulates neuronal signaling, synaptic plasticity, and neurogenesis. The impact of aging on astrocyte morphology is still under ongoing debate. Therefore, this study aimed to characterize astrocyte morphology in the hippocampus of older rats. 2-, 18-, and 20-month-old male Wistar rats were submitted to the object recognition test to assess their short- and long-term memories. CA1, CA2, CA3, and the dentate gyrus were collected for immunohistochemistry analysis and glial fibrillary acid protein (GFAP) immunostaining. Our results indicate that 20-month-old rats did not recognize or discriminate the novel object in the long-term memory test. Also, GFAP staining was greater in the oldest group for all analyzed areas. Morphometric and fractal analysis indicated shorter branch lengths and smaller sizes for astrocytes of 20-month-old rats. Overall, our results suggest that 20-month-old rats have long-term memory impairment, increased GFAP staining, and astrocyte dystrophy. These age-related alterations in astrocyte morphology are a resource for future studies exploring the role of astrocytes in age-related cognitive decline and age-related diseases. (AU) | |
| Processo FAPESP: | 17/10801-1 - Benfotiamina e hormônio tireoideano: influência sobre o metabolismo energético neuronal e a progressão da neurodegeneração em um modelo experimental semelhante à Doença de Alzheimer |
| Beneficiário: | Andréa da Silva Torrão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/12620-0 - Composição de membrana celular e estresse oxidativo no sistema nervoso durante o envelhecimento e a neurodegeneração |
| Beneficiário: | Andréa da Silva Torrão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |